Table 4 Association studies of the TNF genes with tuberculosis.
From: Genetic polymorphisms in TNFgenes and tuberculosis in North Indians
S. No | Reference | Polymorphisms Investigated | Location | Population | Sample size | Results |
|---|---|---|---|---|---|---|
1. | Selvaraj et al. [20] | TNFA -238, -308 and LTA (Nco I) | Promoter; Intron 1 | South Indian | 210 PTB patients and 120 normal controls (NC) | No association with pulmonary TB (PTB). |
2. | Ates et al. [17] | TNFA -308 G/A, -238 G/A, -376 G/A | Promoter | Turkish | 128 TB patients and 80 NC | No association with TB. |
3. | Vejbaesya et al. [21] | TNFA +488, -238, and -308 | Promoter | Thai | 149 TB patients and 147 NC | No association with TB. |
4. | Amirzargar et al. [37] | TNFA -308, G/A -238 | Promoter | Iranian | 41 PTB and 123 NC | -238 polymorphism was associated with pulmonary TB (p = 0.0009). |
5. | Shaw et al. [42] | Linkage study | Markers across the genome | Northern Brazilian | 98 pedigrees, with 704 individuals | Minor role of TNFA in control of TB. |
6. | TNFA -308, G/A -238 | Promoter | Columbia | 138 TB and 419 NC | Association of TNF1 with TB (OR: 1.9, 95%C.I. 1.2-3.1, p = 0.02) | |
7. | Wu et al. [24] | TNFA -308 | Promoter | Chinese | 61 PTB patients and 122 PTB-free miners. | Lack of association with TB. |
8. | Larcombe et al. [26] | TNFA -308 | Promoter | Canadian Aboriginal | Three cohorts n = 61, 42 and 91 for Dené, Cree and healthy Caucasians, respectively | Lack of association with TB. |
9. | Henao et al. [25] | TNFA -308 | Promoter | Colombian | 54 tuberculin-negative NC, 81 tuberculin-positive NC, 140 PTB patients, 30 with pleural TB and 20 with miliary TB | Lack of association with TB. |
10. | Kumar et al. [34] | TNFA -308 | Promoter | Indian | 145 TB and 211 NC | Lack of association with TB. |
11. | Oh et al. [18] | TNFA -308 | Promoter | Korean | 117 NC, 80 newly diagnosed TB patients and 65 patients with recurrent TB | TNFA gene does not affect differential TB susceptibility. |
12. | Sharma et al. [Current] | LTA_NcoI; TNFA -238, -308, -857, -863, -1031 | Intron 1; Promoter | North Indian | 185 TB patients and 155 NC | Lack of association with TB. |