From: An optimal control theory approach to non-pharmaceutical interventions
List of notation | |
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s(t) | proportion of population that is susceptible in the community at time t, s(t) ∈ [0, 1] |
i(t) | proportion of population that is infectious in the community at time t, i(t) ∈ [0, 1] |
r(t) | proportion of population that has recovered in the community at time t, r(t) ∈ [0, 1] |
d(t) | v of population that has died in the community at time t, d(t) ∈ [0, 1] |
x(t) = (s (t), i(t), r(t), d(t)) | state that describes the disease status of a community |
x(0) = (s (0), i(0), r(0), d(0)) | initial disease state of a community |
u(t) | decision variable to model NPI implementation, u(t) ∈ [0, b] |
b | maximum reduction in infection rate β by NPI implementation, b ∈ [0, β] |
T | time when vaccine becomes available, assumed to be exponential with mean Φ |
β | infection rate |
γ | recovery rate |
Ï„ | death rate |
c | relative cost of NPI compared to a single death, c ∈ [0, 1] |
R 0 | basic reproductive number, the average number of secondary cases an infectious individual case will cause |
V (x; u) | value function defined as expected person-days lost |
| control that minimizes the value function |
ψ (s, i) | switching curve |
Ω ={(s, i); s, i ≥ 0, s + i ≤ 1} | state space |
Ω1 = {(s, i) ∈ Ω, u* > 0} | state space where u* > 0 |
Ω2 = {(s, i) ∈ Ω, u* = 0 } | state space where u* = 0 |
| proportion of the control space |
HJB | Hamilton-Jacobi-Bellman equation |