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Table 3 Geometric means for antibody potency and antibody needed for 1:8 opsonization index (Elderly, N = 33; Adults, N = 24)

From: The effect of age on the response to the pneumococcal polysaccharide vaccine

Serotype

Age

Pre-Antibody potency (OT/[IgG])

Post-Antibody potency (OT/[IgG])

Pre-Antibody needed for 1:8 opsonization index (ng/ml)

Post-Antibody needed for 1:8 opsonization index (ng/ml)

  

GMP

95% CI

Sig

GMP

95% CI

Sig

GMI

Sig

GMI

Sig

4

Adult

42

16-111

NS

633

372-1076

P < 0.05

191.4

NS

12.6

P < 0.05

 

Elderly

37

18-73

 

171

77-378

 

218.6

 

46.7

 

6B

Adult

343

102-1153

NS

1349

743-2451

NS

23.3

NS

5.9

NS

 

Elderly

150

57-392

 

710

418-1209

 

53.5

 

11.3

 

9V

Adult

458

145-1448

NS

1112

554-2233

NS

17.5

NS

7.2

NS

 

Elderly

324

126-834

 

813

466-1417

 

24.7

 

9.8

 

14a

Adult

63

23-172

NS

423

202-886

NS

126.1

NS

18.9

NS

 

Elderly

248

71-860

 

426

211-859

 

32.3

 

18.8

 

18C

Adult

641

242-1699

NS

1440

951-2182

NS

12.5

NS

5.6

NS

 

Elderly

286

121-677

 

990

655-1497

 

28.0

 

8.1

 

19A

Adult

ND

 

ND

ND

 

ND

ND

ND

ND

ND

 

Elderly

ND

  

ND

  

ND

   

19F

Adult

12

5-30

NS

276

195-391

P < 0.05

653.2

NS

29.0

P < 0.05

 

Elderly

15

7-31

 

165

128-212

 

535.7

 

48.5

 

23F

Adult

789

309-2012

NS

982

650-1482

P < 0.05

10.1

NS

8.1

P < 0.05

 

Elderly

386

170-879

 

571

396-824

 

20.7

 

14.0

 

6A

Adult

32

11-96

P < 0.05

888

444-1774

P < 0.05

249.1

P < 0.05

9.0

P < 0.05

 

Elderly

5

3-11

 

61

28-134

 

1486.5

 

131.3

 
  1. pre vs post P < 0.05
  2. a For Pn 14 OPKA was done in a limited patients due to lack of sera {Adults (N = 10), Elderly (N = 20)}.