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Table 5 Unadjusted and adjusted analyses of vaccination effectiveness against IPD according to age and risk strata of the patients.

From: Effectiveness of the 23-valent polysaccharide pneumococcal vaccine against invasive pneumococcal disease in people 60 years or older

Characteristics of case patients

No. of sets

No. (% vaccinated)

Unadjusted analysis

Adjusted analysis

  

Case patients

Control subjects

ORa (95% CI)

p value

ORb (95% CI)

p value

Age strata

       

   60-79 yrs

51

17 (33.3)

56 (54.9)

0.36 (0.17-0.78)

0.010

0.32 (0.14-0.74)d

0.007

   80 yrs or more

37

7 (45.9)

48 (64.9)

0.30 (0.10-0.86)

0.026

0.29 (0.09-0.91)e

0.034

Risk strata c

       

   Stratum 1

29

11 (37.9)

36 (62.1)

0.31 (0.11-0.89)

0.029

0.12 (0.03-0.53)f

0.005

   Stratum 2

41

18 (43.9)

53 (64.6)

0.32 (0.13-0.79)

0.014

0.29 (0.11-0.79)g

0.015

   Stratum 3

18

5 (27.8)

15 (41.7)

0.48 (0.12-1.91)

0.294

0.40 (0.09-1.89)h

0.249

  1. NOTE: OR, odds ratio of vaccination versus no vaccination in cases and controls; CI, confidence interval.
  2. aMantel-Haenszel matched Odds Ratio.
  3. bMatched, adjusted Odds Ratio by conditional logistic regression model.
  4. c Among the 29 case patients in risk stratum 1 (possible immunocompromised subjects), main underlying condition for matching was: immunodeficiency in 1 case, cancer in 11 cases (4 genitourinary, 3 haematological, 2 lung, 1 digestive, 1 breast), chronic renal disease in 12 cases (10 chronic renal failure, 1 nephrotic syndrome, 1 dialysis), and corticosteroid therapy in 5 cases. Among the 41 patients in risk stratum 2 (high-risk immunocompetent subjects), main underlying condition for matching was chronic lung disease in 24 cases, chronic liver disease in 3 cases, chronic heart disease in 8 cases and diabetes mellitus in 6 cases. Among the 18 patients in risk stratum 3 (non high-risk immunocompetent subjects), 6 were smokers, and they were matched to their controls according to this condition.
  5. d Adjusted for age, chronic heart disease, smoking and alcoholism.
  6. e Adjusted for age.
  7. f Adjusted for age, stroke and chronic heart disease.
  8. g Adjusted for age, diabetes mellitus, smoking and stroke.
  9. h Adjusted for age and smoking.