Dynamic models of pneumococcal carriage and the impact of the Heptavalent Pneumococcal Conjugate Vaccine on invasive pneumococcal disease

Table 4 Sensitivity analysis

		VT IPD	NVT IPD	Total
Baseline		0	3765	3765
V, vaccine coverage	0.89
	0.5	757	3594	4351
	0.95	0	3765	3765
1/w, Duration of vaccine protection	8.3 years
	5 Years	788	3570	4358
	20 Years	0	3765	3765
Degree	0.76
	0.3	1599	3338	4937
	0.9	0	3765	3765
c_V	0.5
	0	0	3836	3836
	1	2	3710	3712
c_N	0.85
	0	0	9533	9533
	1	0	2921	2921
ε	0.88
	0	0	3765	3765
	0.95	438	3702	4140

Impact of alternative parameter values on the total number of cases of invasive pneumococcal disease (all ages) caused by vaccine and non-vaccine serotypes (VT and NVT respectively) and predicted by the model in the 20 years following PCV7 introduction under Strategy 1 in England and Wales. Base case parameter values are reported in bold.

ISSN: 1471-2334