Table 3 vivo kinetics of killing of C. elegans infected by E. coligrown in urine samples after consumption of the different proanthocyanidins regimens.

3.5 [3-5]

5 [3-7]

6 [5-8]

ND

<0.001

<0.001

ND

NS except for 72 mg

3 [3-6]

4.5 [3-6]

5 [3-6]

ND

<0.001

NS

ND

<0.001

<0.001

3 [3-5]

5 [4-7]

5.5 [4-7]

ND

<0.001

NS

ND

NS except for 36 mg

3 [3-5]

3 [2-4]

5 [4-8]

ND

NS

<0.001

ND

<0.001

4 [3-5]

ND

6.5 [5-9]

7 [5-9]

<0.001

ND

NS

NS

4 [3-5]

ND

5.5 [4-8]

6 [4-8]

<0.001

ND

NS

<0.001

3 [3-5]

ND

5 [4-8]

6 [5-10]

<0.001

ND

NS

NS

4 [3-5]

ND

5 [4-8]

6 [4-9]

<0.001

ND

NS

3 [3-5]

5 [3-7]

5.5 [4-9]

6.5 [5-10]

<0.001

NS

<0.001

NS

ND

3.5 [3-5]

4 [2-6]

5 [3-8]

6 [4-9]

<0.001

<0.001

<0.001

ND

6 [6-7]

LT100 Median (IC95%) in days

P

Placebo

18 mg

36 mg

72 mg

Pl vs 18/36

18 vs 36

36 vs 72

6 h vs 24 h

Sp-Fr vs Ja-Hu

8.5 [7-8]

10 [9-10]

11.5 [11-12]

ND

<0.001

<0.001

ND

NS except for 72 mg

<0.001

7 [6-8]

9 [8-10]

9.5 [9-10]

ND

<0.001

NS

ND

<0.001

7 [6-8]

10 [9-11]

11 [10-12]

ND

<0.001

NS

ND

NS except for 36 mg

7 [6-8]

8 [7-9]

10.5 [10-11]

ND

NS

<0.001

ND

<0.001

<0.001

8 [7-8]

ND

12.5 [12-13]

13 [12-14]

<0.001

ND

NS

NS

7.5 [7-8]

ND

11 [10-12]

12 [11-13]

<0.001

ND

NS

7 [6-8]

ND

12 [11-13]

12.5 [12-13]

<0.001

ND

NS

NS

8 [7-8]

ND

11 [10-12]

11.5 [11-12]

<0.001

ND

NS

7 [6-8]

5 [3-7]

5.5 [4-9]

6.5 [5-10]

<0.001

NS

<0.001

NS

ND

8 [7-8]

4 [2-6]

5 [3-8]

6 [4-9]

<0.001

<0.001

<0.001

ND

14 [13-15]