Characteristics, n (%) | Koutsky & Mao et al. § | Harper et al. | Villa et al. | FUTURE I | FUTURE II | PATRICIA | Muñoz et al. | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vaccine (n = 768) | Control (n = 765) | Vaccine (n = 560) | Control (n = 553) | Vaccine (n = 277) | Control (n = 275) | Vaccine (n = 2723) | Control (n = 2732) | Vaccine (n = 6087) | Control (n = 6080) | Vaccine (n = 9319) | Control (n = 9325) | Vaccine (n = 1911) | Control (n = 1908) | |
Age, mean (SD) | 20.0 (1.6) | 20.1 (1.6) | 20.4 (2.8) | 20.5 (2.7) | 20.2 (1.7) | 20.0 (1.7) | 20.2 (1.8) | 20.3 (1.8) | 20.0 (2.2) | 19.9 (2.1) | 20.0 (3.1) | 20 (3.1) | 34.3 (6.3) | 34.3 (6.3) |
HPV 16 Positivity | ||||||||||||||
DNA | -- | -- | -- | -- | 49 (17.7)† | 51(18.5)† | 238 (8.9) | 227 (8.4) | 543 (9.1) | 545 (9.1) | 516 (5.6) | 478 (5.2) | -- | -- |
Serology | 143 (12.0) | 166 (13.9) | -- | -- | 312 (11.5) | 319 (11.7) | 652 (10.7) | 688 (11.3) | 1544 (16.7) | 1552 (16.8) | -- | -- | ||
HPV 18 Positivity | ||||||||||||||
DNA | -- | -- | -- | -- | 17 (6.1)† | 21 (7.6)† | 86 (3.2) | 83 (3.1) | 230 (3.8) | 242 (4.0) | 215 (2.3) | 216 (2.3) | -- | -- |
Serology | -- | -- | -- | -- | 93 (3.4) | 90 (3.3) | 227 (3.7) | 236 (3.9) | 1076 (11.7) | 1070 (11.6) | ||||
Lifetime no. of sexual partners | ≤ 5 | ≤ 6 | ≤ 4 | ≤ 4 | ≤ 4 | ≤ 6 | No restriction | |||||||
None | 38 (5) | 34 (4) | 90 (16) | 85 (16) | 17 (6) | 16 (6) | -- | -- | -- | -- | 294 (3)†† | 292 (3)†† | 0 (0) | 2 (0.1) |
One | 218 (28) | 200 (26) | 197 (35) | 188 (35) | 80 (29) | 88 (32) | -- | -- | -- | -- | 5862 (63)†† | 5869 (63)†† | 719 (38) | 751 (39) |
Two/Two to five | 173 (23) | 173 (23) | 259 (46) | 242 (45) | 73 (26) | 75 (27) | -- | -- | -- | -- | 1114 (12)†† | 1161 (13)†† | 385 (20) | 362 (19) |
Three/Three or more | 138 (18) | 131 (17) | -- | -- | 67 (24) | 50 (18) | -- | -- | -- | -- | 636 (7)†† | 595 (6)†† | 229 (12) | 223 (12) |
Four/Four or more | 105 (14) | 144 (19) | -- | -- | 40 (14) | 46 (17) | -- | -- | -- | -- | -- | -- | 142 (7) | 130 (7) |
Five/Five or more | 96 (13) | 83 (11) | 14 (3) | 18 (3) | -- | -- | -- | -- | -- | -- | 433 (23) | 437 (23) | ||
Smoking status | ||||||||||||||
Never smoker | -- | -- | 102 (18) | 85 (16) | -- | -- | -- | -- | -- | -- | 6401 (69)* | 6388 (69)* | 923 (48) | 935 (49) |
Former smoker | -- | -- | 164 (30) | 138 (26) | -- | -- | -- | -- | -- | -- | 2706 (29)* | 2726 (29)* | 159 (8) | 148 (8) |
Current smoker | 183 (24) | 190 (25) | 294 (52) | 310 (58) | -- | -- | 696 (26) | 716 (26) | -- | -- | -- | -- | 339 (18) | 332 (17) |
Chlamydia trachomatis | ||||||||||||||
Negative | -- | -- | -- | -- | -- | -- | 2565 (94) | 2545 (93) | 5723 (94) | 5737 (94) | 8155 (88) | 8188 (88) | -- | -- |
Positive | 24 (3) | 19 (3) | -- | -- | -- | -- | 118 (4) | 135 (5) | 258 (4) | 224 (4) | 478 (5) | 475 (5) | -- | -- |
Contraceptive use | ||||||||||||||
Barrier | -- | -- | -- | -- | 63 (23) | 76 (28) | 872 (32) | 874 (32) | -- | -- | -- | -- | 441 (23) | 425 (22) |
Hormonal | -- | -- | -- | -- | 161 (58) | 157 (57) | 1568 (58) | 1539 (57) | 3613 (60) | 3614 (60) | 5544 (59) | 5662 (61) | 596 (31) | 591 (31) |
Behavioral | -- | -- | -- | -- | 48 (17) | 48 (17) | 487 (18) | 498 (18) | -- | -- | -- | -- | 165 (9) | 184 (10) |
Other | -- | -- | -- | -- | 21 (8) | 17 (6) | 125 (5) | 138 (5) | -- | -- | -- | -- | 748 (39) | 749 (39) |
Cytological status at entry | ||||||||||||||
Normal | 656 (88) | 655 (87) | -- | -- | -- | -- | 2360 (89) | 2326 (88) | 5222 (87) | 5242 (89) | 8395 (90) | 8450 (91) | -- | -- |
Abnormal | 84 (11) | 96 (13) | -- | -- | -- | -- | 288 (11) | 316 (12) | 697 (12) | 654 (11) | 908 (10) | 860 (10) | -- | -- |