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Table 2 pncA gene mutation analysis, PZase activity test, and spligotyping of the MDRTB isolates

From: Characteristics of pncA mutations in multidrug-resistant tuberculosis in Taiwan

Mutation site

No. of isolates

Nucleotide substitution

Amino acid change

PZA susceptibility

PZase activity

Spoligotyping

7

1

G→T

Ala(3)→Ser

Resistant

+

Beijing

68

1

G→C

Gly(23)→Ala

Resistant

+

H3

83

1

C→T

Ala(28)→Val

Resistant

+

T1

98

1

A→C

Asp(33)→Ala

Sensitive

+

Beijing

134

1

T→G

Val(45)→Gly

Resistant

-

Beijing

135

1

T→C

Val(45)→Ala

Resistant

-

Orphan strain

161

1

C→T

Pro(54)→Leu

Resistant

+

Orphan strain

165

1a

T→A

Gly(55)→Gly

Resistant

-

Beijing

166

1a

G→T

Gly(55)→Gly

Resistant

-

Beijing

167

1a

A→G

Asp(56)→Cys

Resistant

-

Beijing

170

1a

A→C

His(57)→Pro

Resistant

-

Beijing

171

1, 1a

C→T

His(57)→Pro

Resistant

1+, 1-

Beijing

174

1a

C→A

Phe(58)→Leu

Resistant

-

Beijing

168

1

Ins C

Frameshift

Resistant

-

Beijing

185

1

C→A

Pro(62)→Gln

Resistant

+

Beijing

211

1

C→T

His(71)→Tyr

Resistant

-

Beijing

225

1

A→G

Thr(76)→Ala

Resistant

-

Orphan strain

233

1

G→T

Gly(78)→Gly

Resistant

-

Beijing

248

1

C→G

Pro(83)→Arg

Resistant

+

Orphan strain

254

1

T→C

Leu(85)→Pro

Resistant

-

Beijing

290

1

G→A

Gly(97)→Asp

Resistant

-

Beijing

298

1b

A→G

Thr(100)→Ala

Resistant

-

Orphan strain

442

1b

C→T

Arg(148)→Cys

Resistant

-

Orphan strain

308

1

A→G

Tyr(103)→Cys

Resistant

-

Beijing

207-209

1c

del ACC

-

Resistant

-

Orphan strain

319

1c

G→T

Glu(107)→Glu

Resistant

-

Orphan strain

403

1c

A→G

Thr(135)→Ala

Resistant

-

Orphan strain

461

1c

G→C

Arg(154)→Thr

Resistant

-

Orphan strain

335

2

A→T

Asn(112)→Tyr

Resistant

1+, 1-

Beijing, T2

364

1

C→T

Gln(122)→Gln

Resistant

-

Beijing

394

1

G→A

Gly(132)→Ser

Resistant

+

Orphan strain

395

1

G→A

Gly(132)→Asp

Resistant

-

Orphan strain

401

1

C→T

Ala(134)→Val

Resistant

-

Beijing

416

2

T→C

Val(139)→Ala

Resistant

1+, 1-

Beijing, U

529

1

A→C

Thr(177)→Pro

Resistant

+

Orphan strain

551

1

G→A

Csy(184)→Tyr

Resistant

-

Beijing

-

7

WT

WT

Resistant

4+, 3-

Beijing, Orphan strain

-

29

WT

WT

Sensitive

27+, 2-

Beijing, H3, Orphan strain, T1, T2-T3

  1. a, b, c Multiple mutations within one isolate
  2. WT: wild type