From: Characteristics of pncA mutations in multidrug-resistant tuberculosis in Taiwan
Mutation site | No. of isolates | Nucleotide substitution | Amino acid change | PZA susceptibility | PZase activity | Spoligotyping |
---|---|---|---|---|---|---|
7 | 1 | G→T | Ala(3)→Ser | Resistant | + | Beijing |
68 | 1 | G→C | Gly(23)→Ala | Resistant | + | H3 |
83 | 1 | C→T | Ala(28)→Val | Resistant | + | T1 |
98 | 1 | A→C | Asp(33)→Ala | Sensitive | + | Beijing |
134 | 1 | T→G | Val(45)→Gly | Resistant | - | Beijing |
135 | 1 | T→C | Val(45)→Ala | Resistant | - | Orphan strain |
161 | 1 | C→T | Pro(54)→Leu | Resistant | + | Orphan strain |
165 | 1a | T→A | Gly(55)→Gly | Resistant | - | Beijing |
166 | 1a | G→T | Gly(55)→Gly | Resistant | - | Beijing |
167 | 1a | A→G | Asp(56)→Cys | Resistant | - | Beijing |
170 | 1a | A→C | His(57)→Pro | Resistant | - | Beijing |
171 | 1, 1a | C→T | His(57)→Pro | Resistant | 1+, 1- | Beijing |
174 | 1a | C→A | Phe(58)→Leu | Resistant | - | Beijing |
168 | 1 | Ins C | Frameshift | Resistant | - | Beijing |
185 | 1 | C→A | Pro(62)→Gln | Resistant | + | Beijing |
211 | 1 | C→T | His(71)→Tyr | Resistant | - | Beijing |
225 | 1 | A→G | Thr(76)→Ala | Resistant | - | Orphan strain |
233 | 1 | G→T | Gly(78)→Gly | Resistant | - | Beijing |
248 | 1 | C→G | Pro(83)→Arg | Resistant | + | Orphan strain |
254 | 1 | T→C | Leu(85)→Pro | Resistant | - | Beijing |
290 | 1 | G→A | Gly(97)→Asp | Resistant | - | Beijing |
298 | 1b | A→G | Thr(100)→Ala | Resistant | - | Orphan strain |
442 | 1b | C→T | Arg(148)→Cys | Resistant | - | Orphan strain |
308 | 1 | A→G | Tyr(103)→Cys | Resistant | - | Beijing |
207-209 | 1c | del ACC | - | Resistant | - | Orphan strain |
319 | 1c | G→T | Glu(107)→Glu | Resistant | - | Orphan strain |
403 | 1c | A→G | Thr(135)→Ala | Resistant | - | Orphan strain |
461 | 1c | G→C | Arg(154)→Thr | Resistant | - | Orphan strain |
335 | 2 | A→T | Asn(112)→Tyr | Resistant | 1+, 1- | Beijing, T2 |
364 | 1 | C→T | Gln(122)→Gln | Resistant | - | Beijing |
394 | 1 | G→A | Gly(132)→Ser | Resistant | + | Orphan strain |
395 | 1 | G→A | Gly(132)→Asp | Resistant | - | Orphan strain |
401 | 1 | C→T | Ala(134)→Val | Resistant | - | Beijing |
416 | 2 | T→C | Val(139)→Ala | Resistant | 1+, 1- | Beijing, U |
529 | 1 | A→C | Thr(177)→Pro | Resistant | + | Orphan strain |
551 | 1 | G→A | Csy(184)→Tyr | Resistant | - | Beijing |
- | 7 | WT | WT | Resistant | 4+, 3- | Beijing, Orphan strain |
- | 29 | WT | WT | Sensitive | 27+, 2- | Beijing, H3, Orphan strain, T1, T2-T3 |