Sub-optimal CD4 reconstitution (Cases) N = 34 | Optimal CD4 reconstitution (Controls) N = 64 | Super-optimal CD4 reconstitution (Controls) N = 30 | P value* | |
---|---|---|---|---|
At baseline | ||||
Age (yrs) [median (IQR)] | 36 (31-42) | 33 (30-38) | 35 (31-43) | 0.509 |
Female gender [n (%)] | 21 (62) | 49 (77) | 26 (87) | 0.066 |
BMI [median (IQR)] | 20 (19-23) | 20 (19-23) | 20 (19-23) | 0.935 |
CD4 cells/μl [median (IQR)] | 111 (62-151) | 105 (40-176) | 115 (97-185) | 0.447 |
< 100 cells/μl [n(%)] | 20 (59) | 35 (55) | 15 (30) | 0.779 |
ART regimen | ||||
D4T-3TC-NVP/EFZ [n (%)] | 17 (50) | 43 (67) | 22 (73) | |
ZDV-3TC-NVP/EFZ [n (%)] | 17 (50) | 21 (33) | 8 (27) | 0.116 |
Hemoglobin [ median (IQR)] | 12 (11-13) | 11 (10-13) | 11 (10-13) | 0.473 |
After 4 years of ART | ||||
CD4 cells/μl [median (IQR)] | 220 (183-248) | 407 (334-456) | 985 (438-1290) | < 0.001 |
< 350 cells/μl [n(%)] | 34 (100) | 19 (30) | 0 (0) | < 0.001 |
BMI [median (IQR)] | 21 (19-25) | 22 (20-24) | 22 (20-24) | 0.062 |
Hemoglobin [ median (IQR)] | 14 (12-15) | 13 (12-14) | 13 (12-14) | 0.969 |
Hepatitis B positive [n] | 1 | 5 | 1 | 0.033 |
ART regimen | ||||
D4T-3TC-NVP/EFZ [n (%)] | 13 (38) | 41 (64) | 17 (57) | |
ZDV-3TC-NVP/EFZ [n (%)] | 21 (62) | 18 (28) | 13 (43) | |
TDF-3TC-NVP/EFZ [n (%)] | 0 (0) | 5 (8) | 0 (0) | 0.008 |