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Table 2 T-cell immune activation, cell exhaustion and peripheral blood parameters among patients with and without suboptimal CD4 reconstitution after 4 years of antiretroviral therapy.

From: High T-cell immune activation and immune exhaustion among individuals with suboptimal CD4 recovery after 4 years of antiretroviral therapy in an African cohort

Parameters measured after 4 years of ART Suboptimal CD4 reconstitution
(Cases) N = 34
Super-Optimal CD4 reconstitution
(Controls) N = 30
P-value * Adjusted OR
(95% CI)
P-value
Immune activation      
CD4 HLADR+ CD38+ [Median (IQR)] 7.9 (4.9-16.4) 2.8 (2.0-3.6) < 0.001 5.7 (1.4-23.0) 0.014
CD8 HLADR+ CD38+ [Median (IQR)] 22.5 (15.3-44.9) 10.3 96.3-15.1) < 0.001 0.8 (0.6-1.1) 0.107
Cell exhaustion      
CD4 PD1+ [Median (IQR)] 34.3 (17.6-78.8) 7.3 (4.7-9.4) < 0.001 1.5 (1.1-2.1) 0.022
CD8 PD1+ [Median (IQR)] 30.6 (13.4-82.9) 7.9 (6.2-9.5) < 0.001 1.2 (0.9-1.5) 0.130
Peripheral blood parameters      
Hemoglobin (mg/dl) [Median (IQR)] 13 (12-14) 14 (12-15) 0.293   
MCV (fl) [Median (IQR)] 102 (96-112) 109 (98-112) 0.264   
Total white blood cell count
[Median (IQR)]
3530 (3000-4050) 5050 (4240-5720) 0.003   
Lymphocytes % [Median (IQR)] 37 (30-46) 45 (36-51) 0.278   
Neutrophils % [Median (IQR)] 45 (40-59) 42 (38-50) 0.820   
Eosinophils % [Median (IQR)] 4 (1-8) 2 (1-3) 0.012   
Platelet count nx103 [Median (IQR)] 235 (205-284) 292 (214-318) 0.359   
  1. *Wilcoxon rank-sum test, ¥ Chi square, MCV, mean corpuscular volume