Table 2 T-cell immune activation, cell exhaustion and peripheral blood parameters among patients with and without suboptimal CD4 reconstitution after 4 years of antiretroviral therapy.
Parameters measured after 4 years of ART | Suboptimal CD4 reconstitution (Cases) N = 34 | Super-Optimal CD4 reconstitution (Controls) N = 30 | P-value * | Adjusted OR (95% CI) | P-value |
|---|---|---|---|---|---|
Immune activation | Â | Â | Â | Â | Â |
CD4 HLADR+ CD38+ [Median (IQR)] | 7.9 (4.9-16.4) | 2.8 (2.0-3.6) | < 0.001 | 5.7 (1.4-23.0) | 0.014 |
CD8 HLADR+ CD38+ [Median (IQR)] | 22.5 (15.3-44.9) | 10.3 96.3-15.1) | < 0.001 | 0.8 (0.6-1.1) | 0.107 |
Cell exhaustion | Â | Â | Â | Â | Â |
CD4 PD1+ [Median (IQR)] | 34.3 (17.6-78.8) | 7.3 (4.7-9.4) | < 0.001 | 1.5 (1.1-2.1) | 0.022 |
CD8 PD1+ [Median (IQR)] | 30.6 (13.4-82.9) | 7.9 (6.2-9.5) | < 0.001 | 1.2 (0.9-1.5) | 0.130 |
Peripheral blood parameters | Â | Â | Â | Â | Â |
Hemoglobin (mg/dl) [Median (IQR)] | 13 (12-14) | 14 (12-15) | 0.293 | Â | Â |
MCV (fl) [Median (IQR)] | 102 (96-112) | 109 (98-112) | 0.264 | Â | Â |
Total white blood cell count [Median (IQR)] | 3530 (3000-4050) | 5050 (4240-5720) | 0.003 | Â | Â |
Lymphocytes % [Median (IQR)] | 37 (30-46) | 45 (36-51) | 0.278 | Â | Â |
Neutrophils % [Median (IQR)] | 45 (40-59) | 42 (38-50) | 0.820 | Â | Â |
Eosinophils % [Median (IQR)] | 4 (1-8) | 2 (1-3) | 0.012 | Â | Â |
Platelet count nx103 [Median (IQR)] | 235 (205-284) | 292 (214-318) | 0.359 | Â | Â |