Figure 5
From: Evidence for an enterovirus as the cause of encephalitis lethargica
(Mag. 26K). EL case #28065B. This image illustrates a region of neuropil. There is extensive damage to the axons. There is swelling and obliteration of the myelin sheaths and dispersion of the nerve fibers. VLP were not observed in the capillary endothelium, neuropil, or cellular elements other than in the neurons. The TEM finding of involvement of the neuropil in EL is confirmed by the immunohistochemical staining of neuropil with anti-poliovirus antibody in EL tissue (see Figure 16). Bar = 1.2 μm.