Table 2 CD4 count six months after ART initiation and CD4 changes estimated by adjusted linear mixed model, relative to the viral load six and 12 months after starting ART (HIV-RNA threshold 10,000 copies), ART-LINC of IeDEA
Variables | Mean CD4 cell count at M6 (cells/μL) | 95% CI | p value |
|---|---|---|---|
Viral load at M6 | <0.0001 | ||
<500 | 289* | 277;301 | |
[500–10,000[ (vs <500) | −3 | −26;+20 | |
≥10,000 (vs <500) | −82 | −106;-58 | |
Gender | 0.0005 | ||
Male vs female | −18 | −29;+8 | |
Age at starting ART (years) | 0.0451 | ||
[16-30[ vs. ≥40 | +13 | −1;+27 | |
[30-35[ vs. ≥40 | −3 | −16;+10 | |
[35-40[ vs. ≥40 | −7 | −21;+7 | |
Year of starting ART | 0.0111 | ||
Prior to 2004 vs. up to 2003 | +14 | +3;+25 | |
Stage at starting ART | <0.0001 | ||
III vs. A,B/I,II | −50 | −62;-38 | |
AIDS/IV vs. A,B/I,II | −46 | −58;-33 | |
Unknown vs. A,B/I,II | −5 | −24;+14 | |
Mean CD4 cell count change from M6 to M18 (cells/μL) | |||
Viral load at M6 and M12 * | <0.0001 | ||
Viral load <500 at M6 and <500 at M12 | +90 | +71;+108 | |
Viral load <500 at M6 and [500–10,000[ at M12 | +49 | +7;+91 | |
Viral load <500 at M6 and ≥10,000 at M12 | +1 | −47;+49 | |
Viral load = [500–10,000[ at M6 and <500 at M12 | +64 | +37;+90 | |
Viral load = [500–10,000[ at M6 and = [500–10,000[ at M12 | +23 | −22;+68 | |
Viral load = [500–10,000[ at M6 and ≥10,000 at M12 | −25 | −76;+26 | |
Viral load ≥10,000 at M6 and <500 at M12 | +87 | +59;+115 | |
Viral load ≥10,000 at M6 and = [500–10,000[ at M12 | +46 | 0;+93 | |
Viral load ≥10,000 at M6 and ≥10,000 at M12 | −1 | −51;+48 |