Alterations of leptin in the course of inflammation and severe sepsis

BMC Infectious Diseases

Table 1 Baseline characteristics of 104 patients suffering from severe sepsis at day 1

	All patients (n = 104)	DAA + (n = 26)	DAA − (n = 78)	p value †
Age (years)*	64.0 ± 13.5	56.6 ± 15.0	66.5 ± 12.1	0.002
Gender (n)
Male	62	16	46	0.8
Female	42	10	32
Body mass index (BMI) *	26.4 ± 0.8	25.2 ± 2.5	26.6 ± 0.9	0.6
Heart rate (beats/min) *	84 ± 23.6	85 ± 20.8	84 ± 24.5	0.76
APACHE II score *	28.3 ± 5.4	28.6 ± 6.5	28.1 ± 5.0	0.9
Primary site of infection (n)
Lung	51	10	41
Urinary	6	2	4
Cerebral	5	2	3
Cardiac	12	4	8	0.3
Intra-abdominal	7	-	7
Skin	2	-	2
Unknown	21	8	13
CRP (mg/l)*	164 ± 126	206 ± 151	151 ± 115	0.2
Creatinine (mg/dl)*	2.6 ± 2.1	3.0 ± 2.3	2.5 ± 2.0	0.2
White blood cells (10⁹/l)*	16.4 ± 8.0	16.0 ± 9.7	16.5 ± 7.5	0.4
Platelets (10⁹/l)*	210 ± 117	202 ± 115	213 ± 118	0.5
aPTT (sec)*	40.7 ± 24.4	42.2 ± 25.5	40.2 ± 24.2	0.4
Antithrombin III (%)*	63.5 ± 19.5	61.4 ± 17.1	64.3 ± 20.6	0.8
D-dimer (μg/ml)*	5.0 ± 3.8	3.0 ± 2.0	5.5 ± 4.1	0.4
Bilirubin (mg/dl)*	1.7 ± 1.8	2.6 ± 2.3	1.4 ± 1.5	0.04
Death (n)	53	17	36	0.9

* Data are presented as mean ± standard deviation (SD).† p values are calculated for the comparison between DAA+ patients with DAA- patients.

ISSN: 1471-2334