Procalcitonin and procalcitonin kinetics for diagnosis and prognosis of intravascular catheter-related bloodstream infections in selected critically ill patients: a prospective observational study

Table 3 Diagnostic significance of PCT, PCT kinetics, WBC, and CRP for CRBSI during ICU stay

	AUC (95% CI)	Cut-off	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	LR(+)	LR(−)	Accuracy (%)
PCT D0 [ng/ml]	0.990 (0.972 – 1.000)	>0.70	92.3 (73.4 – 98.7)	100 (80.0 – 100)	100.0	90.9	n.a.	0.08	95.7
ΔPCT_{D-1, D0} [ng/ml]	0.982 (0.941 – 1.000)	>0.20	100 (84.0 – 100)	95.0 (73.1 – 99.7)	96.3	100.0	20.0	0.0	97.8
ΔPCT_{D-2, D0} [ng/ml]	0.992 (0.975 – 1.000)	>0.20	100 (84.0 – 100)	95.0 (73.1 – 99.7)	96.3	100.0	20.0	0.0	97.8
ΔPCT_{D-3, D0} [ng/ml]	0.980 (0.939 – 1.000)	>0.20	96.2 (78.4 – 99.8)	95.0 (73.1 – 99.8)	96.2	95.0	19.2	0.04	95.6
ΔPCT_{D-4, D0} [ng/ml]	0.982 (0.946 – 1.000)	>0.20	96.2 (78.4 – 99.8)	95.0 (73.1 – 99.8)	96.2	95.0	19.2	0.04	95.6
WBC D0 [10 ³/μl]	0.539 (0.369 – 0.709)	>15.64	57.7 (37.2 – 76.0)	60.0 (36.4 – 80.0)	65.2	52.2	1.44	0.71	58.7
CRP D0 [mg/dl]	0.603 (0.438 – 0.768)	>16.90	50.0 (30.4 – 69.6)	70.0 (45.7 – 87.2)	68.4	51.9	1.67	0.71	58.7

AUC (95% confidence interval, CI), positive (PPV) and negative (NPV) predictive value, LR(+) likelihood ratio positive, and LR(−) likelihood ratio negative.

ISSN: 1471-2334