Estimated health and economic impact of quadrivalent HPV (types 6/11/16/18) vaccination in Brazil using a transmission dynamic model

Table 1 Demographic, sexual behavior, cervical cancer screening, and disease model parameters

Parameter	Estimate		Source
Demographic variables
Total population size	203,429,773		[15]
Annual all-cause mortality rate by sex and age	(Data not shown)		[16]
Sexual behavior variables
Annual mean number of sexual partners by sex	Male	Female	[17]
15-19 yrs	1.65	1.29
20-24 yrs	1.89	1.07
25-34 yrs	1.40	1.06
35-44 yrs	1.22	0.98
45-59 yrs	1.15	0.79
Screening variables
	Female
Cervical cancer screening rate, % past 3 years	70		[18–20]
Cervical cancer screening rate, % past year			[18]
<20 yrs	0.0
20-29 yrs	26.0
30-34 yrs	30.3
35-39 yrs	32.6
40-44 yrs	30.8
45-49 yrs	30.0
50-54 yrs	28.6
55-69 yrs	26.4
>70 yrs	10.0
Disease variables
Cervical cancer mortality rates, per year			[21]
Localized cervical cancer
<40 yrs	0.135
40-49 yrs	0.066
50-59 yrs	0.090
60-69 yrs	0.100
>70 yrs	0.130
Regional cervical cancer
<40 yrs	0.202
40-49 yrs	0.100
50-59 yrs	0.136
60-69 yrs	0.150
>70 yrs	0.195
Distant cervical cancer
<40 yrs	0.808
40-49 yrs	0.399
50-59 yrs	0.543
60-69 yrs	0.602
>70 yrs	0.780
Population level hysterectomy rates, % per year
< 25 yrs	0.01
25-29 yrs	0.03
30-34 yrs	0.12
35-39 yrs	0.36
40-44 yrs	0.67
45-54 yrs	0.58
55-69 yrs	0.20
>70 yrs	0.20

ISSN: 1471-2334