Clinicopathological correlates in HIV seropositive tuberculosis cases presenting with jaundice after initiating antiretroviral therapy with a structured review of the literature

Table 3 Chronological selected blood indices for patient 1 and 5

Week since starting HAART		Alb	Total Bil	ALT	ALP	GGT	Hb	WCC	plt	lactate	INR
Patient 1
−2	First visit to ARV clinic	23	5	13	152	73	7.4	6.5	394	n/a
0		26	11	20	131	89	8.0	5.5	314	n/a
+2	Presents with jaundice 2 weeks post HAART	20	88*	127	833	429	7.0	3.1	803	2.9	1.3
+4	Starts 14 days prednisolone	17	62	99	1310	673	7.0	2.9	736	n/a	1.0
+8	Clinically improved	24	22	49	667	330	7.9	3.9	448	n/a	1.0
Patient 5
−2	First visit to ARV clinic	22	18	34	119	35	11.3	5.4	364	n/a	n/a
0	After 2 weeks TB treatment starts HAART	24	21	45	133	57	9.3	4.4	682	n/a	n/a
+2	Has been found to have jaundice 10 days post HAART; TB treatment stopped	21	56*	60	115	99	n/a	n/a	n/a	2.7	1.3
+3	With resolving jaundice and clinical deterioration TB treatment restarted	26	26	48	138	93	9.5	2.6	460	2.6	1.2
+4	Return of jaundice and liver biopsy suggests DILI – TB treatment stopped	21	97	67	187	148	9.2	2.7	424	1.6	1.4

* > 85% conjugated bilirubin.
Alb albumin in g/L, Bil total total bilirubin μmol/L, ALT alanine aminotransteraseiu/L, ALP alkaline phosphatase iu/L, GGT Gamma-glutamyltranspeptidaseiu/L., Hb haemoglobin in g/dL; WCC = white cell count (total) x10⁹/L; plt = platelets x10⁹/L; lactate is measured in mmol/L; INR = international normalised ratio.

ISSN: 1471-2334