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Table 3 Comparison between patients who succeeded with non-invasive ventilation and those who did not*

From: Clinical features and risk factors for severe and critical pregnant women with 2009 pandemic H1N1 influenza infection in China

Characteristic

Non-invasive ventilation

 

With successful outcomes‡ (n = 38)

With failure outcomes (n = 45)

Pvalue

ORuadj (95% CI)

ORadj (95% CI)

Age (Mean ± SD, years)

26.1 ± 4.3

25.5 ± 4.3

0.61

0.97 (0.88-1.08)

 

BMI, median (IQR)

25.2 (24.4-28.8)

27.0 (24.5-30.4)

0.31

1.08 (0.93-1.25)

1.06 (0.72-1.56)

Gestational age, median (IQR)

32 (26-35)

32 (28-36)

0.96

0.99 (0.93-1.07)

0.97 (0.82-1.15)

Respiratory diseases (%)

2/37 (5.4)

1/44 (2.3)

0.48

0.42 (0.04-4.79)

 

Pneumonia (%)

37/38 (97.4)

43/45 (95.6)

0.65

1.76 (0.15-20.23)

 

Symptoms and Lab findings

     

T ≥ 38°C(%)

33/37 (89.2)

39/42 (92.9)

0.86

1.57 (0.33-7.56)

 

Dyspnoea (%)

24/38 (63.2)

31/44 (70.5)

0.43

0.68 (0.26-1.76)

 

Hemoptysis (%)

6/38 (15.8)

9/43 (20.9)

0.62

1.34 (0.42-4.23)

 

CNS symptom ※ (%)

1/38 (2.6)

9/44 (20.5)

0.04

9.51 (1.15-79.03)

1.48 (0.96-13.45)

WBC (×109/L), (Mean ± SD)

7.2 ± 3.6

7.6 ± 3.9

0.63

1.03 (0.91-1.16)

 

Hb (g/L) (Mean ± SD)

105.9 ± 15.6

99.0 ± 15.7

0.06

0.97 (0.94-1.02)

 

PLT (×109/L) (Mean ± SD)

155.5 ± 44.1

151.7 ± 56.7

0.75

1.00 (0.99-1.01)

 

ALT (U/L) (Mean ± SD)

43.3 ± 60.9

48.9 ± 61.2

0.69

1.002 (0.99-1.01)

 

CRP (mg/L) (Mean ± SD)

71.2 ± 52.9

90.8 ± 56.6

0.36

1.01 (0.99-1.02)

 

PaO2/FiO2

     

PaO2/FiO2 ≥ 300 (%)

7/24 (29.2)

3/33 (9.1)

 

Referent

 

PaO2/FiO2 201 to 300 (%)

3/24 (12.5)

4/33 (12.1)

0.27

3.11 (0.41-23.93)

 

PaO2/FiO2 ≤ 200 (%)

14/24 (58.3)

26/33 (78.8)

0.06

4.33 (0.97-23.83)

 

APACHE II score, median (IQR)

7 (7-11)

10 (6-14)

0.01

1.14 (1.02-1.27)

1.20 (0.97-1.49)

Septic shock (%)

1/24 (4.2)

17/32 (53.1)

0.002

27.93 (3.34-33.47)

32.87 (1.91-566.52)

Acute liver damage **(%)

4/25 (16.0)

12/28 (42.9)

0.04

3.93 (1.07-14.52)

5.17 (0.47-56.37)

Pleural effusion (%)

11/35 (31.4)

12/40 (30.0)

0.89

1.07 (0.40-2.86)

 
  1. ORuadj, unadjusted odds ratio; ORadj, Adjusted odds ratio; CI, confidence Interval; BMI, body mass index; IQR, interquartile range; APACHE II, acute physiology and chronic health evaluation II; ICU, intensive care unit
  2. * Date are presented as no./total no., if otherwise stated. Percentages are based on women with complete information in the respective categories
  3. ‡ included 38 patients survived after receiving NIV
  4. ¶ included 7 patients died of respiratory failure who received NIV, 38 patients who received NIV firstly, then changed to invasive ventilation
  5. ※ CNS system symptoms: refers to one or more of the following symptoms: insomnia, restlessness, hallucination, headache, dizziness and abnormal behaviour.
  6. ** Acute liver damage: AST or ALT > 70 U/L, or Tbil > 2 mg/dL.
  7. Variables included in multivariate model: BMI, Gestational age, CNS symptom, APACHE II score, septic shock, acute liver damage
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BMC Infectious Diseases

ISSN: 1471-2334

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