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Table 5 Factors predicting clinical failure

From: Adherence to recommendations by infectious disease consultants and its influence on outcomes of intravenous antibiotic-treated hospitalized patients

 

Success

Failure

P

OR

N

983

190

Bivariate

Multivariate

Age (mean ± SD)

64.1 ± 17.6

68.9 ± 14.7

<0.001

p= 0.100

Coming from healthcare facilities

183 (18.6)

56 (29.5)

0.001

p= 0.215

Prior hospitalization (previous 30 days)

255 (25.9)

68 (35.8)

0.005

p= 0.625

Charlson index

2.07 ± 2.07

3.17 ± 2.16

<0.001

1.19 (1.10-1.28) p<0.001

Heart failure

358 (36.4)

94 (49.5)

0.001

p= 0.123

Renal insufficiency

281 (28.6)

86 (45.3)

<0.001

p= 0.155

Diabetes

408 (41.5)

93 (48.9)

0.058

p= 0.744

Malignancies

384 (39.0)

104 (54.7)

<0.001

p= 0.775

Immunosuppressive therapy

178 (18.1)

47 (24.7)

0.034

p= 0.262

Malnutrition

74 (7.5)

34 (17.9)

<0.001

2.00 (1.22-3.26) p=0.006

Nosocomial infection

187 (25.3)

88 (51.8)

<0.001

4.12 (2.27-7.48) p<0.001

Microbiological tests

652 (66.3)

160 (84.2)

<0.001

p= 0.020

Complete adherence

184 (18.7)

15 (7.9)

0.001

0.35 (0.19-0.64) p=0.001

Treatment initiated in Emergency room

777 (79.0)

138 (72.6)

0.051

p= 0.023

Adequate initial treatment

147 (15.0)

9 (4.7)

<0.001

0.39 (0.19-0.80) p=0.010

Modification of initial treatment

306 (31.1)

43 (22.6)

0.019

p= 0.140

Length of hospitalization

18.9 (27.0)

36.3 (37.4)

<0.001

1.01 (1.01-1.02) p<0.001

  1. It shows only significant variables in the bivariate analysis. “Clinical failure” was used as dependent variable.