Year | Total | Incidence rateb
| Age groups | Â | Â | Â |
|---|
|  |  |  | 0-11 mths | 1-4 yrs | 5-9 yrs | 10-14 yrs | 15-19 yrs | 20-24 yrs | 25-29 yrs | ≥ 30 yrs | among vaccinees |
|---|
2000
| 105 | 0.7 | 2 | 22 | 15 | 11 | 18 | 9 | 4 | 24 | n.a. |
2001
| 276 | 1.7 | 23 | 50 | 27 | 39 | 65 | 15 | 9 | 48 | n.a. |
2002
c
| 222 | 1.4 | 13 | 39 | 30 | 26 | 47 | 17 | 5 | 45 | 0c
|
2003
d
| 42 | 0.3 | 11 | 6 | 0 | 1 | 0 | 6 | 0 | 18 | 0 |
2004
| 17 | 0.1 | 1 | 1 | 1 | 0 | 0 | 1 | 2 | 11 | 0 |
2005
| 4 | 0.03 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 |
2006
| 4 | 0.03 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0 |
2007
| 9 | 0.06 | 2 | 0 | 1 | 0 | 1 | 1 | 0 | 4 | 0 |
2008
| 11 | 0.07 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 8 | 0 |
2009
| 10 | 0.06 | 1 | 1 | 0 | 0 | 1 | 0 | 2 | 5 | 0 (1)e
|
2010
| 6 | 0.04 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 (1)e
|
- Surveillance data 2000-2009 are obtained from annual reports "Bacterial Meningitis in the Netherlands" published by "Netherlands Reference Laboratory for Bacterial Meningitis" [5]. Data from 2010 are not published yet
- n.a.; not applicable
-
a MenC disease cases are defined as culture and/or PCR-proven presence of MenC bacteria in cerebrospinal fluid and/or blood
-
b Incidence rate is defined as the annual incidence rate of MenC disease per 100.000 inhabitants of the Netherlands
-
c In the Netherlands, MenC conjugate vaccine was introduced in Spring 2002
-
d The case fatality rate (CFR) calculated from 58 patients with MenC disease cases occurring between January 2003-May 2005 was 5.2% [6]
-
e One case of MenC disease occurred in a vaccinated 16 years old female (2009), and one case in a vaccinated 19 years old male (2010). Both persons had an immune disorder
