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Table 1 M.tb target antigens used for T cell stimulation

From: Pattern recognition and cellular immune responses to novel Mycobacterium tuberculosis-antigens in individuals from Belarus

M.tbtarget protein ID Biology
Cyclopropane fatty acyl phospholipid synthase Rv0447c Involved in lipid formation and synthesis of long fatty acids, resistance to (oxidative) stress and survival
Mycobacterium bovis mycocerosic acid synthase gene (mas) Rv2940c (mas) multifunctional enzyme that catalyzes the synthesis of very long chain multiple methyl branched fatty acids called mycocerosic acids present in slow-growing pathogenic mycobacteria, major mycobacterial cell wall complex
PPE family proteins Rv3347c Accounts for about 10% of the genomic M.tb coding capacity. Form a source for antigenic variation among different M.tb strains
  Rv1917c (p) Induces functional maturation of dendritic cells through an integrated cross talk between PI3K-MAPK and NF-κB signaling cascades and facilitates a Th2 phenotype
PE_PGRS 11 family proteins Rv0754 (p) Rv0978c (p) Cell wall associated protein, induces activation and maturation of human dendritic cells as well as secretion of key proinflammatory cytokines
Probable molybdopterin-guanine dinucleotide biosynthesis protein Rv2453c Involved in metabolism and respiration, associated with non replicating bacteria
Secreted antigen 85A and 85B
Hypotheticall cell wall protein
Rv3804c (85A) (p)
Rv1886c (85B)
(both as peptides and protein)
Rv0959
Mycolyl transferase activity. Responsible for the high affinity of mycobacteria to fibronectin
Cell- wall associated protein
Probable lipoprotein LPRJ Rv1690 Contains possible signal sequence and a prokaryotic membrane lipoprotein lipid attachment site
Secreted ESAT-6 like protein ESXH (TB10.3)
ESAT-6
Rv3019
Rv3875 (p)
M.tb pathogenicity
Possible glycosyl transferase Rv2957c, Rv2958c Rv2962c cellular metabolism and lipid formation, contributes to M.tb survival in macrophages
Possible hemolysin -like protein Rv1085c virulence and adaption
Probable isocitrate dehydrogenase Rv0066c cellular metabolism
Low molecular weight protein antigen 7 esxH Rv0288 (TB10.4) peptides and protein bacterial virulence
  1. List of M.tb target antigens used for T-cell stimulation. Proteins are designated with (p) unless stated otherwise