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Table 2 Characteristics of HSCT patients with and without invasive fungal infections

From: Invasive fungal infection among hematopoietic stem cell transplantation patients with mechanical ventilation in the intensive care unit

 

Invasive fungal infection

(n = 20)

Without invasive fungal infection

(n = 40)

P-value

Median age at ICU admission

30 ± 7.9

37 ± 11.0

0.024

*

Gender

   Male

12 (60%)

15 (37.5%)

0.099

 

   Female

8 (40%)

25 (62.5%)

  

Early vs. late ICU admission after HSCT (day)

209 ± 158.2

73 ± 56.6

0.068

 

ICU length of stay (day)

10.7 ± 7.6

12.8 ± 14.5

0.533

 

Underlying disease

   ALL

4 (20%)

5 (12.5%)

  

   AML

8 (40%)

7 (17.5%)

  

   CML

3 (15%)

9 (22.5%)

  

   Multiple myeloma

1 (5%)

3 (7.5%)

  

   Hodgkin's disease

2 (10%)

2 (5%)

  

   Other hematological disease

2 (10%)

14 (34.5%)

  

Type of transplantation

   Allo-PBSCT/Allo-BMT

13 (65%)/4 (20%)

24 (60%)/5 (12.5%)

  

   Auto-PBSCT/Auto-BMT

3 (15%)/0

10 (25%)/1 (2.5%)

  

GVHD

16 (80%)

15 (37.5%)

0.003

**

CMV infection

7 (35%)

6 (15%)

0.101

 

Neutropenia

16(80%)

32 (80%)

0.099

 

Concurrent bacteremia

12 (60%)

26 (65%)

0.705

 

High dose corticosteroid

13 (65%)

10 (25%)

0.003

*

APACHE II score

22 ± 5.7

27 ± 9.8

0.014

*

SOFA score

10.45 ± 2.7

13 ± 4.0

0.020

*

ICU mortality

17 (85%)

36 (90%)

0.676

 
  1. *: p < 0.05; **: p < 0.01.
  2. Data represent as mean ± S.D or number (percentage).
  3. Abbreviations: HSCT: hematopoietic stem cell transplantation; ALL: acute lymphoid leukemia; AML: acute myeloid leukemia; CML: chronic myeloid leukemia; MDS: myelodysplastic syndrome; PBSCT: peripheral blood stem cell transplantation; BMT: bone marrow transplantation; GVHD: graft versus host disease; APACHE II: acute physiology and chronic health evaluation II; SOFA score: sequential organ failure assessment score; and ICU: intensive care unit.