Invasive fungal infection among hematopoietic stem cell transplantation patients with mechanical ventilation in the intensive care unit

Table 3 Univariate and multivariate analysis of clinical variables associated with invasive fungal infection

	Univariate analysis						Multi-variate analysis
Variable	Odds Ratio	95% C.I.			P-value		Odds ratio	95% C.I.			P-value
Age > 30	0.333	0.108	-	1.034	0.053
Gender	0.900	0.300	-	2.704	0.099
Late ICU admission (> 40 days after HSCT)	6.500	1.916	-	22.052	0.002	**	1.003	1.001	-	1.006	0.008	*
Type of transplantation	0.465	0.114	-	1.906	0.281
GVHD	6.667	1.874	-	23.714	0.002	*	8.291	1.687	-	40.746	0.009	*
CMV infection	3.051	0.862	-	10.799	0.101
Neutropenia (ICU admission)	1.000	0.261	-	3.826	0.099
Concurrent bacteremia	0.808	0.267	-	2.440	0.705
High dose corticosteroid use	5.571	1.738	-	17.856	0.003	*	9.459	2.040	-	43.867	0.004	*
APACHE II > 25	0.130	0.033	-	0.518	0.002	*
SOFA > 12	0.250	0.071	-	0.880	0.025	*
ICU Mortality	0.810	0.173	-	3.792	0.676

a. If cells had expected count less than 5, Fisher's Exact Test was used.
b. *: p < 0.05; **: p < 0.01
Abbreviations: C.I.: confidence interval; HSCT: hematopoietic stem cell transplantation; GVHD: graft versus host disease; CMV: cytomegalovirus; APACHE II: acute physiology and chronic health evaluation II; SOFA score: sequential organ failure assessment score; ICU: intensive care unit.

ISSN: 1471-2334