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Table 4 Association between maternal cytokine gene polymorphisms and newborns’ biological parameters: multivariate analysis

From: Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns

Maternal cytokine gene (n)

Haemoglobin (g/dl) (SD)a

P b

Anaemia OR [CI95]c

P d

IL-10 −1082 genotypes:

    

 GG (47)

15.1 (0.3)

   

 GA and AA (529)

14.6 (0.3)

0.07

OR GA and AA vs GG = 1.81 [0.98-3.32]

0.06

IL-10 −819 genotypes:

    

 CC (191)

14.8 (0.2)

   

 CT and TT (385)

14.6 (0.2)

0.14

OR CT and TT vs CC = 1.46 [1.02-2.10]

0.04

IL-10 −592 genotypes:

    

 CC (191)

14.7 (0.1)

   

 CA and AA (385)

14.4 (0.2)

0.13

OR CA and AA vs CC = 1.36 [0.95-1.95]

0.09

IL-10 −1082 /IL-10 −819 /IL-10 −592 haplotypes:

    

 No IL10-ATA (196)

14.8 (0.2)

   

 1 or 2 copies IL10-ATA (380)

14.6 (0.2)

0.13

OR 1 or 2 copies IL10-ATA vs. no IL10-ATA = 1.45 [1.02-2.08]

0.04

  1. a 5 missing values.
  2. b analysis adjusted on maternal anaemia (Hb < 11 g/dl) and low birthweight (< 2500 g).
  3. c newborn’s anaemia defined as Hb < 15 g/dl.
  4. d analysis adjusted on maternal anaemia and age.
  5. P values < 0.05 are in bold.