Table 5 Association between maternal cytokine gene polymorphisms and antibody levels to P. falciparum antigens in mothers: multivariate analysis
Antibody response | Maternal cytokine gene (n) | Antibody levels (μg/ml)a(SD) | P |
|---|---|---|---|
IgM to AMA-1 | Â | Â | Â |
|  | IL-10 −1082 genotypes: |  |  |
|  |  GG (47) | 13.9 (3.3) |  |
|  |  GA (223) | 17.0 (3.5) | 0.08 b |
|  |  AA (306) | 20.0 (3.7) |  |
IgG to MSP-1 | Â | Â | Â |
|  | IL-4 −590 genotypes: |  |  |
|  |  CC and CT (218) | 49.0 (5.5) |  |
|  |  TT (358) | 32.8 (7.0) | 0.02 c |
IgG to MSP-2/3D7 | Â | Â | Â |
|  | IL-4 −590 genotypes: |  |  |
|  |  CC and CT (218) | 95.5 (10.3) |  |
|  |  TT (358) | 70.3 (11.9) | 0.03 d |
|  | IL-10 −1082 genotypes: |  |  |
|  |  GG and GA (270) | 68.2 (6.2) |  |
|  |  AA (306) | 92.9 (12.2) | 0.04 d |
IgG to MSP-2/FC27 | IL-4 −590 genotypes: |  |  |
|  |  CC (25) | 147.7 (61.7) |  |
|  |  CT (193) | 98.0 (62.7) |  |
|  |  TT (358) | 85.4 (62.8) | 0.02 b |
IgG to GLURP-R2 e | Â | Â | Â |
|  | IL-4 −590 genotypes: |  |  |
|  |  CC (25) | 23.2 (6.9) |  |
|  |  CT and TT (551) | 38.3 (7.6) | 0.05 d |
|  | IL-10 −1082 /IL-10 −819 /IL-10 −592 haplotypes: |  |  |
|  |  No or 1 copy IL10-ATA (489) | 38.6 (3.0) |  |
|  |  2 copies IL10-ATA (87) | 24.6 (7.6) | 0.07 d |