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Table 1 Patient characteristics according to CRT

From: X4 viruses are frequently archived in patients with long-term HIV infection but do not seem to influence the “inflamm-aging” process

 

R5

X4

p value

N patients

68 (58%)

50 (42%)

 

Male gender (N,%)

52 (76%)

36 (72%)

0.6

Age (years, mean ± SD)

51.2 ± 5.6

50.6 ± 5.9

0.1

Foreign nationality (N,%)

1 (1.5%)

1 (2.0%)

0.8

HIV-1 non B subtype (N,%)

15 (22%)

7 (14%)

0.3

Risk factor (N,%)

   

 - parenteral

44 (65%)

27 (54%)

 

 - sexual

23 (34%)

21 (42%)

0.4

ART duration (years; median, IQR)

13 (9–16)

14 (10–16)

0.5

 - NRTIs

13 (9–16)

14 (10–16)

0.6

 - NNRTIs

4 (1–7)

4 (2–6)

1.0

 - PIs

7 (5–9)

6 (5–12)

0.5

Past use of mono- or bi-therapy (N,%)

43 (63%)

35 (70%)

0.8

Previous AIDS events (N,%)

7 (10%)

10 (20%)

0.2

Serious non-AIDS events (N,%)

19 (39%)

7 (14%)

0.07

HBsAg pos (N,%)

9 (13%)

4 (8%)

0.1

Anti-HCV pos (N,%)

51 (75%)

30 (60%)

0.1

pVL (log10 cp/ml;median, IQR)

3.2 (3.2-4.8)

4.1 (3.2-8.9)

0.1

Aviremic pts (N,%)

53 (78%)

36 (72%)

 

CD4+ cell count (median, IQR)

   

 - absolute (n/mmc)

658 (219–185)

558 (109–1219)

0.1

 - percentage (%)

31 (24–53)

28 (11–52)

0.1

Nadir CD4+ cell count

   

 - absolute (median n/mmc;, IQR)

137 (90–616)

87 (27–382)

0.005

 - percentage (%)

11 (7–27)

8 (2–32)

0.01

  1. Legend: N = number, SD = standard deviation; IQR = InterQuartile Range; pVL: HIV-1 plasma viral load.