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Table 3 Sensitivity analysis: incremental cost-effectiveness ratio (ICER) of HPV vaccination* in Estonia, model estimates.

From: The epidemiological and economic impact of a quadrivalent human papillomavirus (hpv) vaccine in Estonia

 

ICER € per QALYs

Base case

4889

Screening characteristics

 

Under hypothetical improved cervical screening program**

6167

Vaccine characteristics

 

Assuming no HPV 6/11 protection

5771

Duration of protection = 20 years

8090

Vaccination characteristics

 

Low vaccine coverage (70%)

4444

High vaccine coverage (95%)

5212

Costs characteristics

 

Cost of diagnosis and treatment +20%

4744

Cost of diagnosis and treatment −20%

5037

Cost of vaccine - 10%

4351

Cost of vaccine + 10%

5454

Health utility values

 

Cost per life year saved (no quality of life adjustments)

6746

Discount rate

 

Discount rate 0%

1517

Discount rate 5%

11148

  1. * HPV6/11/16/18 related cervical cancer and genital warts.
  2. **Vaccination program introduced alongside hypothetical improved cervical screening program.