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Table 3 Pre-S region mutations and deletions

From: Molecular characterization of hepatitis B virus in liver disease patients and asymptomatic carriers of the virus in Sudan

 

Clinical group

Genotype

Pre-S2 S tart codon

Deletions

    

Region

Nucleotides

Amino acids

Region and functions affected

ID

    

Size

Position

Size

position

 

SDAC024

CR

D

ATG

Pre-S2

21

35-55a

7

16-22a

 

SDAC048

CR

D

ATG

Pre-S1

72

2998-3069

24

51-74

S promoter, Transactivator domain

SDAC083

CR

D

ATG

Pre-S2

21

35-55

7

16-22

 

SDAC097

CR

D

GTG b

Pre-S 2

9

45- 53

3

19-21

 

SDAC098

CH

D

ATG

Pre-S1

18

3129-3146

6

94-99

Hsc70 binding site, CCAAT binding factor (CBF) binding site, Cytosolic anchorage determinant (CAD)

SDAC112

ASC

D

ATG

Pre-S2

6

49-54

2

20-21

 

SDAC118

CR

D

ATG

Pre-S2

54

4-57

18

5 to 22

pHSA binding site, Viral secretion

SDAC107

CR

D

ATA

-

-

-

-

-

-

SDAC090

CR

D

ATA

-

-

-

-

-

-

SDAC058

CR

E

ATG

Pre-S2

9

58-66c

3

20-22c

Transactivator domain

SDAC059

HCC

E

GTG

Pre-S2

12

52-63

4

18-21

Transactivator domain

SDAC088

HCC

E

ATG

Pre-S2

12

52-63

4

18-21

Transactivator domain

SDAC095

HCC

E

ATG

Pre-S2

15

52-66

5

18-22

Transactivator domain

SDAC067

ASC

E

GTG

-

-

-

-

-

-

SDAC113

ASC

A

ACA

-

-

-

-

-

-

  1. a nucleotide or amino acid position relative to genotype D (GU456684).
  2. b mutant pre-S2 start codon italicized.
  3. c nucleotide or amino acid position relative to genotype E (AB205191).