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Table 3 Results of the performance of the original clinical model compared with that of different models extended with genetic variables selected by the lasso method

From: Addition of host genetic variants in a prediction rule for post meningitis hearing loss in childhood: a model updating study

SNP / SNP combination

Log likelihood values

AUC of ROC

95% CI of AUC of ROC

p-valuea

Clinical model

 

0.856

0.794-0.909

 

TLR4

0.2802

0.854

0.786-0.911

0.780

TLR9 -1237

−0.5675

0.861

0.798-0.915

0.570

NOD2 - SNP13

0.8338

0.855

0.796-0.908

0.404

TLR2 + 2477 and TLR4

−0.9646

0.875

0.816-0.925

0.335

TLR2 -19634 and TLR4

−0.8836

0.869

0.812-0.920

0.377

TLR2 + 2477 and TLR9 + 2848

0.0843

0.855

0.780-0.918

0.933

  1. a AUC combined SNP model versus clinical model.
  2. Abbreviations:
  3. SNP: Single nucleotide polymorphism.
  4. AUC: Area Under the Curve.
  5. ROC: Receiver Operator Curve.
  6. 95% CI: 95% confidence interval.
  7. TLR: Toll-like receptor.
  8. NOD: Nucleotide Oligomerization Domain protein.