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Table 2 Univariate and multivariate GEE models for estimating determinants of progression to sepsis, severe sepsis, or septic shock during the first week of hospital stay

From: Clinical course of sepsis, severe sepsis, and septic shock in a cohort of infected patients from ten Colombian hospitals

Covariables

Univariate analysis

Multivariate analysis

 

OR

95% CI

P value

OR

95% CI

P value

Age (for each year of increase)

1.00

(1.00 – 1.01)

<0.001

1.00

(1.00 – 1.00)

0.445

Sex

  

  Female

1

Reference

1

Reference

  Male

1.07

(1.00 – 1.15)

0.037

0.97

(0.92 – 1.02)

0.236

Site

  

  Community

1

Reference

1

Reference

  Hospital

1.12

(1.04 – 1.20)

0.002

1.03

(0.96 – 1.09)

0.409

Source of infection

  

  Urinary

1

Reference

1

Reference

  Respiratory

1.53

(1.38 – 1.68)

<0.001

1.21

(1.11 – 1.33)

<0.001

  Skin and soft tissues

0.81

(0.73 – 0.91)

<0.001

0.91

(0.84 – 1.00)

0.041

  Intra-abdominal

1.64

(1.46 – 1.84)

<0.001

1.32

(1.20 – 1.46)

<0.001

  Other infections

1.33

(1.22 – 1.44)

<0.001

1.16

(1.08 – 1.25)

<0.001

Comorbidities

      

  Without comorbidities

1

Reference

1

Reference

  With any comorbidity

1.30

(1.21 – 1.40)

<0.001

1.01

(0.95 – 1.07)

0.774

SOFA score (0 – 24, for each unit of increase)

1.21

(1.20 – 1.22)

<0.001

1.16

(1.14 – 1.17)

<0.001

APACHE II score (0 – 67, for each unit of increase)

1.08

(1.07 – 1.08)

<0.001

1.02

(1.02 – 1.03)

<0.001

Blood cultures

  

Not requested

1

Reference

1

Reference

Negative

1.17

(1.09 – 1.27)

<0.001

0.96

(0.91 – 1.03)

0.281

  Gram-positive bacteria

1.46

(1.28 – 1.66)

<0.001

0.99

(0.88 – 1.11)

0.867

  Gram-negative bacteria

1.58

(1.41 – 1.75)

<0.001

1.01

(0.93 – 1.11)

0.748