Table 3 Univariate and multivariate Cox models for 7-day mortality with clinical stage as time-dependent covariate
Covariables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Age (for each year of increase) | 1.02 | 1.01 – 1.02 | <0.001 | 1.01 | 1.00 – 101 | 0.039 |
Sex | ||||||
Female | 1 | Reference | 1 | Reference | ||
Male | 1.02 | 0.81 – 1.27 | 0.875 | 0.98 | 0.76 – 1.27 | 0.899 |
Site | ||||||
Community | 1 | Reference | 1 | Reference | ||
Hospital | 1.29 | 1.02 – 1.62 | 0.034 | 1.33 | 0.98 – 1.80 | 0.064 |
Source of infection | ||||||
Urinary | 1 | Reference | 1 | Reference | ||
Respiratory | 2.70 | 1.85 – 3.95 | <0.001 | 1.76 | 1.12 – 2.77 | 0.014 |
Skin and soft tissues | 1.07 | 0.68 – 1.69 | 0.776 | 1.22 | 0.73 – 2.02 | 0.441 |
Intra-abdominal | 2.36 | 1.52 – 3.65 | <0.001 | 1.50 | 0.90 – 2.48 | 0.118 |
Other infections | 2.34 | 1.65 – 3.31 | <0.001 | 1.89 | 1.28 – 2.80 | 0.001 |
Comorbidities | ||||||
Without comorbidities | 1 | Reference | 1 | Reference | ||
With any comorbidity | 1.52 | 1.17 – 1.98 | 0.002 | 0.88 | 0.65 – 1.20 | 0.426 |
SOFA score (0 – 24, for each unit of increase) | 1.24 | 1.21 – 1.27 | <0.001 | 1.09 | 1.04 – 1.15 | 0.001 |
APACHE II score (0 – 67, for each unit of increase) | 1.13 | 1.11 – 1.14 | <0.001 | 1.07 | 1.04 – 1.10 | <0.001 |
Blood cultures | ||||||
Not requested | 1 | Reference | 1 | Reference | ||
Negative | 1.07 | 0.82 – 1.40 | 0.603 | 0.91 | 0.67 – 1.23 | 0.546 |
Gram-positive bacteria | 1.37 | 0.88 – 2.11 | 0.158 | 0.83 | 0.50 – 1.36 | 0.454 |
Gram-negative bacteria | 1.04 | 0.68 – 1.58 | 0.858 | 0.59 | 0.36 – 0.95 | 0.031 |
Classification of infection (progression to) | ||||||
Infection without sepsis | 1 | Reference | 1 | Reference | ||
Sepsis | 2.75 | 1.47 – 5.15 | 0.002 | 1.76 | 0.93 – 3.33 | 0.081 |
Severe sepsis | 4.95 | 2.71 – 9.06 | <0.001 | 2.13 | 1.13 – 4.03 | 0.019 |
Septic shock | 13.51 | 7.41 – 24.64 | <0.001 | 3.00 | 1.50 – 5.98 | 0.002 |