Reduced thrombin formation and excessive fibrinolysis are associated with bleeding complications in patients with dengue fever: a case–control study comparing dengue fever patients with and without bleeding manifestations

Table 3 Thrombin generation test

TGT	Controls (n = 24)	DF without bleeding (n = 9)	DF with bleeding (n = 9)	P ^#
Lag phase *	9.1 (1.8-17.7)	12.3 (3.1 -17.1) ^±	11.6 (3.1 – 22.6) ^±	0.021
Thrombin peak (nM) *	338.7 (145.1 - 512.2)	251.6 (70.7 – 432.3)	199.0 (15.9 – 394.1) ^±	0.009
Velocity-index *	59.1 (13.3 – 128.7)	37.3 (6.7 – 193.2)	32.8 (12.6-73.0) ^±	0.033
AUC *	3753.4 (2228.9–4905.6)	3367.5 (1512.9-4284.2)	2274.5 (180.5-3829.2) ^±	0.002

* Median and range.
^# P values were calculated using the Kruskal-Wallis analysis.
^± Tukey test detected places of differences. In lag phase the differences were in DF with and also in DF without bleeding vs. controls. In thrombin peak, velocity index and AUC the difference was significant in the DF with bleeding group vs. controls.
This table shows the TGT results in controls and patients with DF, according to the presence of bleeding manifestations.

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