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Table 1 In vitro antifungal susceptibility testing of 240 clinical isolates to 6 antifungal agents

From: Surveillance of the prevalence, antibiotic susceptibility, and genotypic characterization of invasive candidiasis in a teaching hospital in China between 2006 to 2011

Species (No of isolates)

Antifungal agent

MIC (μg/ml)

% Resistant

  

Range

MIC50 a

MIC90 a

 

All isolates (240)

Fluconazole

1– > 128

1

4

7.5

Voriconazole(except C. glabrata)

0.06– > 8

0.064

0.25

5.4

Itraconazole(limit C.albicans only)

0.125– > 4

0.125

0.5

4.9

Caspofunginb

0.032–2

0.125

0.5

0

Flucytosine

< 4–16

4

4

 

Amphotericin B

< 0.5–0.5

0.5

0.5

 

C. albicans (136)

Fluconazole

1– > 128

1

2

6.6

Voriconazole

0.06– > 8

0.064

0.064

2.9

Itraconazole

0.125– > 4

0.125

0.125

4.9

Caspofunginb

0.032–0.38

0.094

0.19

0

Flucytosine

< 4–16

4

4

 

Amphotericin B

< 0.5–0.5

0.5

0.5

 

C.tropicalis (59)

Fluconazole

1– > 128

1

128

10.6

Voriconazole

0.06– > 8

0.064

8

10.6

Itraconazole

0.125– > 4

0.125

4

 

Caspofunginb

0.032–0.38

0.094

0.19

0

Flucytosine

< 4–4

4

4

 

Amphotericin B

< 0.5–0.5

0.5

0.5

 

C. paraps-ilosis (25)

Fluconazole

< 1–2

1

1

0

Voriconazole

< 0.06–0.25

0.064

0.064

0

Itraconazole

< 0.125–0.25

0.125

0.125

 

Caspofunginb

0.38–2

1

1.5

0

Flucytosine

< 4– > 16

4

16

 

Amphotericin B

< 0.5–0.5

0.5

0.5

 

C.glabrata (20)

Fluconazole

1–64

2

64

15.0

Voriconazole

0.06–8

0.125

8

 

Itraconazole

0.125– > 4

0.5

4

 

Caspofunginb

0.047–0.38

0.19

0.25

0

Flucytosine

< 4–4

4

4

 
 

Amphotericin B

< 0.5–0.5

0.5

0.5

 
  1. Footnote: aMIC50, 50% minimal inhibitory concentration; MIC90: 90% minimal inhibitory concentration. bCaspofungin tested using E-test strips.