Skip to main content

Table 1 Characteristics of severe and non-severe leukopenia in a French cohort of 148 patients with S. aureus- necrotizing pneumonia, between 1986 and 2010

From: Severe leukopenia in Staphylococcus aureus-necrotizing, community-acquired pneumonia: risk factors and impact on survival

Variables

Group 1

Group 2

Pvalue

 

(≤3.000 leukocytes/mL) n=62

(>3 000 leukocytes/mL) n=86

 

Demographic information

   

Age

   

0-30

32 (51.6)

55 (64.0)

0.132

>30

30 (48.4)

31 (36.0)

 

Gender, M:F (ratio)

29:33 (46.8)

59:27 (68.6)

0.008

Medical history

   

Smoking

7 (12.5)

16 (19.5)

0.278

Alcohol

1 (1.7)

3 (3.7)

0.479

Steroid treatment

2 (3.3)

7 (8.3)

0.222

Respiratory failure

0 (0)

3 (3.5)

0.138

Personal history of furuncles or skin abscess

1 (2.0)

12 (16.0)

0.011

Before hospital admission

Period between onset of symptoms and admissiona

3 (2-4)

3 (2-5)

0.684

Influenza-like illness

46 (79.3)

41(49.4)

<0.001

SSTIb

6 (9.7)

27 (31.4)

0.002

Clinical features within the first 48 h of hospitalization

 

PRISM scorea, b

27 (20-35)

6 (4-11)

<0.001

SAPS II scorea, b

67 (39-80)

28 (15-61.8)

<0.001

Platelet count/mL

92,000 (46,500-176,500)

204,000 (145,000-370,000)

<0.001

Fever, temperature >39°C

46 (64.2)

70 (81.4)

0.294

Generalized rash 24 h

5 (8.3)

6(7.0)

0.760

Airway hemorrhage

39 (62.9)

20 (23.3)

<0.001

Pleural effusion

16 (27.1)

49 (57.6)

<0.001

Radiological consolidation

  

0.001

Unilobar

6 (9.8)

30 (34.9)

 

Multilobar

48 (78.7)

44 (51.2)

 

ARDSb

47 (77.0)

15 (18.1)

<0.001

Methicillin resistance (mecAgene)

15 (24.2)

20 (23.3)

0.895

Treatment and outcome

Mechanical ventilation

57 (91.9)

37 (43.0)

<0.001

Inotrope drugs

52 (91.2)

21 (26.3)

<0.001

Time to deatha

2 (1-6)

2 (1-2.75)

0.216

Appropriate antibiotics introduced in first 24 h of h hospitalization

46 (75.4)

65 (75.6)

0.161

Mortality

47 (75.8)

14 (16.3)

<0.001

Percentage of deaths attributed to S. aureus infection

47 (100)

13 (92.9)

0.065

  1. aContinuous variables are indicated as median, first and third quartiles and categorical variables as number (%).
  2. bSSTI: skin and soft tissue infection, PRISM: Pediatric Risk of Mortality; SAPS II: Simplified Acute Physiology Score; ARDS: acute respiratory distress syndrome.