Variables | Group 1 | Group 2 | Pvalue |
---|---|---|---|
(≤3.000 leukocytes/mL) n=62 | (>3 000 leukocytes/mL) n=86 | ||
Demographic information | |||
Age | |||
0-30 | 32 (51.6) | 55 (64.0) | 0.132 |
>30 | 30 (48.4) | 31 (36.0) | |
Gender, M:F (ratio) | 29:33 (46.8) | 59:27 (68.6) | 0.008 |
Medical history | |||
Smoking | 7 (12.5) | 16 (19.5) | 0.278 |
Alcohol | 1 (1.7) | 3 (3.7) | 0.479 |
Steroid treatment | 2 (3.3) | 7 (8.3) | 0.222 |
Respiratory failure | 0 (0) | 3 (3.5) | 0.138 |
Personal history of furuncles or skin abscess | 1 (2.0) | 12 (16.0) | 0.011 |
Before hospital admission | |||
Period between onset of symptoms and admissiona | 3 (2-4) | 3 (2-5) | 0.684 |
Influenza-like illness | 46 (79.3) | 41(49.4) | <0.001 |
SSTIb | 6 (9.7) | 27 (31.4) | 0.002 |
Clinical features within the first 48 h of hospitalization | |||
PRISM scorea, b | 27 (20-35) | 6 (4-11) | <0.001 |
SAPS II scorea, b | 67 (39-80) | 28 (15-61.8) | <0.001 |
Platelet count/mL | 92,000 (46,500-176,500) | 204,000 (145,000-370,000) | <0.001 |
Fever, temperature >39°C | 46 (64.2) | 70 (81.4) | 0.294 |
Generalized rash 24 h | 5 (8.3) | 6(7.0) | 0.760 |
Airway hemorrhage | 39 (62.9) | 20 (23.3) | <0.001 |
Pleural effusion | 16 (27.1) | 49 (57.6) | <0.001 |
Radiological consolidation | 0.001 | ||
Unilobar | 6 (9.8) | 30 (34.9) | |
Multilobar | 48 (78.7) | 44 (51.2) | |
ARDSb | 47 (77.0) | 15 (18.1) | <0.001 |
Methicillin resistance (mecAgene) | 15 (24.2) | 20 (23.3) | 0.895 |
Treatment and outcome | |||
Mechanical ventilation | 57 (91.9) | 37 (43.0) | <0.001 |
Inotrope drugs | 52 (91.2) | 21 (26.3) | <0.001 |
Time to deatha | 2 (1-6) | 2 (1-2.75) | 0.216 |
Appropriate antibiotics introduced in first 24 h of h hospitalization | 46 (75.4) | 65 (75.6) | 0.161 |
Mortality | 47 (75.8) | 14 (16.3) | <0.001 |
Percentage of deaths attributed to S. aureus infection | 47 (100) | 13 (92.9) | 0.065 |