Variable | Hazard ratios(95%CI)in univariate1models | P-value | Hazard ratios(95%CI)in one multivariate model | P-value |
---|---|---|---|---|
Male (versus female) 2 | 0.952 (0.703, 1.290) | 0.752 | 0.949 (0.697, 1.291) | 0.739 |
Age (1 year change) | 1.002 (0.991, 1.013) | 0.728 | 1.002 (0.991, 1.013) | 0.758 |
MSM (versus no MSM) | 1.145 (0.905, 1.448) | 0.260 | (Not included) | |
ART naïve, time on ART: | (Not included) | |||
ART-experienced | 0.640 (0.455, 0.902) | 0.011* | ||
ART-naivety uncertain | 0.926 (0.640, 1.339) | 0.682 | ||
Time on ART | 0.990 (0.897, 1.093) | 0.841 | ||
(1 year change) | ||||
No ART (reference) | 1.000 | — | ||
ART naïve, time on ART classified: | (Not included) | |||
ART-naivety uncertain | 0.940 (0.650-1.360) | 0.743 | ||
ART-experienced < 1year | 0.901 (0.631-1.287) | 0.567 | ||
Time on ART 1-<2 years | 0.488 (0.303-0.786) | 0.003* | ||
Time on ART 2-<3 years | 0.379 (0.219-0.655) | 0.001* | ||
Time on ART 3-<4 years | 0.469 (0.265-0.828) | 0.009* | ||
Time on ART > 4- years | 0.635 (0.364-1.108) | 0.110 | ||
No ART (reference) | 1.000 | — | ||
ART regimen, specific | ||||
NNRTI-regimen | 0.557 (0.396, 0.783) | 0.001* | 0.530 (0.375, 0.748) | <0.001* |
PI-regimen | 0.703 (0.512, 0.965) | 0.029* | 0.624 (0.451, 0.862) | 0.004* |
Regimen with other | 0.717 (0.469, 1.095) | 0.123 | 0.729 (0.469, 1.131) | 0.158 |
Drugs/combinations | ||||
Treatment interruption | 1.153 (0.716, 1.859) | 0.558 | 1.108 (0.686, 1.789) | 0.675 |
No ART (reference) | 1.000 | — | 1.000 | — |
CD4-rise (of 100 cells/μl) | 0.939 (0.898, 0.983) | 0.006* | 0.918 (0.875, 0.963) | 0.001* |
Immunosuppressive medication (yes versus no) | 1.733 (1.060, 2.832) | 0.028* | 1.510 (0.921, 2.477) | 0.103 |
Retrospective documentation (yes versus no) | 0.575 (0.452, 0.730) | <0.001* | 0.582 (0.455, 0.745) | <0.001* |