Skip to main content

Table 6 Multivariate analysis for independent risk factors for colistin-associated nephrotoxicity at day 7 and at the EOT

From: Trough colistin plasma level is an independent risk factor for nephrotoxicity: a prospective observational cohort study

Day 7

Variable

Odds ratio (95% CI)

P

Age

1.01 (0.95-1.08)

0.75

Charlson score

1.04 (0.71-1.52)

0.84

Albumin

0.89 (0.33-2.42)

0.83

1CMS cumulative dose at day 7

0.99 (0.94-1.04)

0.73

2Cmin

4.7 (2.38-9.29)

< 0.001

End of treatment

Variable

Odds ratio (95% CI)

P

Age

0.98 (0.93-1.03)

0.51

Charlson score

1.3 (1.01-1.57)

0.036

Albumin

0.59 (0.25-1.38)

0.22

CMS cumulative dose

0.99 (0.98-1)

0.38

CMS duration treatment

1.03 (0.98-1.08)

0.24

Cmin

2.1 (1.33-3.42)

0.002

3NSAID use

5.09 (0.9-28.54)

0.64

Loop diuretic use

1.97 (0.61-6.38)

0.25

Co-administration of > 2 nephrotoxic drugs

2.61 (1–6.7)

0.049

  1. 1CMS:colistinmethanesulfonate sodium. 2Cmin: colistin trough plasma concentrations at steady state. 3NSAID: non-steroidal anti-inflammatory drugs.