Table 1 Univariate analysis of covariates including patient drug exposures, comorbidities, and the association with hospitalized SSSTI
Variable | Case | Control | Odds Ratio | 95% | P-Value |
|---|---|---|---|---|---|
N = 97 | N = 291 | Confidence Interval | |||
Frequency (Percent) | Frequency (Percent) | ||||
MEDICATONS | |||||
Anti-TNF Drugs | |||||
Biologics 90 days before index date | 19 (19.59) | 53 (18.15) | 1.107 | 0.604, 2.028 | 0.74 |
Biologics Anytime Before Index | 29 (29.90) | 70 (23.97) | 1.388 | 0.815, 2.363 | 0.23 |
ETANERCEPT Anytime Before Index | 16 (16.49) | 42 (14.38) | 1.184 | 0.631, 2.22 | 0.60 |
INFLIXIMAB IV Anytime Before Index | 3 (3.09) | 13 (4.45) | 0.857 | 0.178, 4.126 | 0.85 |
ADALIMUMAB Anytime Before Index | 1 (1.03) | 7 (2.40) | 0.404 | 0.47, 3.462 | 0.41 |
Monoclonals Only: INFLIXIMAB/ ADALIMUMAB | 7 (7.22) | 14 (4.79) | 0.633 | 0.178, 2.245 | 0.48 |
Concomitant Medications | |||||
Methotrexate within 30 days of index date | 20 (20.62) | 89 (30.48) | 0.578 | 0.325, 1.029 | 0.06 |
Prednisone within 30 days of index date | 51 (52.58) | 107 (36.64) | 1.921 | 1.206, 3.058 | <0.01 |
Prednisone 6 mo. prior to index date | 56 (57.73) | 144 (49.32) | 1.447 | 0.898, 2.334 | 0.13 |
Azathioprine within 30 days of index date | 3 (3.09) | 4 (1.37) | 2.250 | 0.504, 10.053 | 0.29 |
Leflunomide within 30 days of index date | 7 (7.22) | 25 (8.56) | 0.819 | 0.345, 1.940 | 0.65 |
Hydroxychlorquine within 30 days of index date | 23 (23.71) | 84 (28.77) | 0.784 | 0.462, 1.330 | 0.36 |
Sulfasalazine within 30 days of index date | 6 (6.19) | 38 (13.01) | 0.454 | 0.187, 1.104 | 0.08 |
Antibiotic use 90 days prior to index date | 86 (88.66) | 51 (17.47) | 44.984 | 16.41, 123.28 | <0.01 |
Concomitant Inflammatory Diseases | |||||
Psoriasis | 10 (10.31) | 33 (11.30) | 0.892 | 0.411, 1.934 | 0.77 |
Crohns† | 3 (3.09) | 3 (3.09) | 2.805 | 0. 564, 13.962 | 0.21 |
Ulcerative Colitis† | 3 (3.09) | 4 (1.37) | 2.121 | 0.473, 9.514 | 0.33 |
Ankylosing Spondylitis† | 4 (4.12) | 7 (2.40) | 1.714 | 0.502, 5.86 | 0.39 |
Uveitis† | 2 (2.06) | 0 (0.00) | 0.138 | - ∞, 0.573 | 0.13 |
Co-morbidities | |||||
Diabetes mellitus | 36 (37.11) | 53 (18.15) | 2.514 | 1.528, 4.134 | <0.01 |
Chronic Kidney Disease | 15 (15.46) | 11 (3.77) | 4.558 | 1.981, 10.487 | <0.01 |
Neoplasm | 9 (9.28) | 12 (4.11) | 2.464 | 0.993, 6.116 | 0.50 |
Chronic Bronchitis | 44 (45.36) | 81 (27.74) | 2.133 | 1.327, 3.429 | 0.01 |
Gastroesophageal Reflux | 36 (37.11) | 94 (32.19) | 1.282 | 0.777, 2.114 | 0.33 |
HIV† | 0 (0.00) | 1 (0.34) | 0.333 | 0.009, ∞ | 1.00 |
Prior History of Skin Infection (SSSTI) | 26 (26.80) | 17 (5.82) | 5.729 | 2.870, 11.434 | <0.01 |
Discharge 3 Months Prior | 14 (14.43) | 20 (6.85) | 2.245 | 1.098, 4.590 | 0.03 |
Chronic Liver Disease† | 2 (2.06) | 0 (0.00) | 0.167 | -∞, 0.7732 | 0.17 |
Other Bacterial Infections | |||||
Pneumonia† | 4 (4.12) | 1 (0.34) | 12 | 1.341, 107.63 | 0.03 |
Septic Arthritis† | 1 (1.03) | 1 (1.03) | .333 | 0.004, 26.166 | 0.89 |