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Table 2 Results of the final multivariate model of patient drug exposures and comorbidities and their association with hospitalized SSSTI

From: “Serious skin & soft tissue infections in rheumatoid arthritis patients taking anti-tumor necrosis factor alpha drugs: a nested case–control study”

Variable

Case

Control

Odds Ratio

95%

Adjusted p value

N = 97

N = 291

Confidence

Interval

Frequency (Percent)

Frequency (Percent)

Anti-TNF drug exposure

19 (19.59)

53 (18.15)

1.107

0.604, 2.028

0.92

Diabetes mellitus

36 (37.11)

53 (18.15)

2.514

1.528, 4.134

<0.01

Prior SSSTI

26 (26.80)

17 (5.82)

5.729

2.870, 11.434

<0.01

  1. Multivariate adjustment for RA severity, diabetes mellitus, chronic kidney disease, chronic bronchitis, prior history of skin infection, pneumonia, discharge 3 months prior, prednisone use within 30 days of the index date and antibiotic use 90 days prior to the index. Age and race were also included in the initial multivariate model to assess potential confounding.