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Table 2 Meta-analysis results for association between oipA on/off and presence/absence status and PUD and GC

From: Association of presence/absence and on/off patterns of Helicobacter pylori oipA gene with peptic ulcer disease and gastric cancer risks: a meta-analysis

Variable

No. of studies

No. of cases/controls

OR (95% CI)

P value

I2

Phet a

PB-D test b

For oipA on/off studies

PUD vs. gastritis/FD

All

10

439/583

3.97 (2.89,5.45)

<0.001

22.30%

0.238

 

Region

      

0.681

Europe

7

250/285

3.75 (2.54,5.53)

<0.001

57.20%

0.029

 

Asia

2

28/138

2.42 (0.61,9.55)

0.208

32.90%

0.222

 

America

4

161/160

4.77 (2.65,8.56)

<0.001

0.00%

0.902

 

Detection technique

      

0.376

PCR based-sequencing

11

359/503

3.83 (2.71,5.40)

<0.001

41.10%

0.075

 

Immunoblot

2

80/80

4.42 (1.98,9.83)

<0.001

0.00%

0.492

 

Age

      

0.014

Adult

11

351/470

3.26 (2.26,4.69)

<0.001

16.90%

0.282

 

Children

2

88/113

7.03 (3.71,13.34)

<0.001

0.00%

0.319

 

GU vs. gastritis/FD

2

33/115

2.85 (0.94,8.69)

0.065

0.00%

0.368

 

DU vs. gastritis/FD

6

205/241

3.83 2.32,6.34)

<0.001

0.00%

0.628

 

GC vs. gastritis/FD

All

5

144/287

2.43 (1.45,4.07)

0.001

16.80%

0.308

 

Region

      

0.697

Europe

1

9/29

4.89 (0.54,44.57)

0.159

/

/

 

Asia

2

24/138

1.08 (0.29,3.99)

0.909

0.00%

0.796

 

America

3

111/120

2.47 (1.36,4.51)

0.003

51.30%

0.128

 

Detection technique

      

0.034

PCR based-sequencing

5

104/247

1.75 (0.96,3.18)

0.066

0.00%

0.634

 

Immunoblot

1

40/40

6.00 (1.79,20.15)

0.004

/

/

 

For oipA presence/absence studies

PUD vs. gastritis/FD

All

7

267/486

1.93 (0.60,6.25)

0.278

85.70%

<0.001

 

Region

      

<0.001

Asia

8

189/291

2.64 (0.85,8.20)

0.092

76.40%

<0.001

 

Africa

1

78/195

0.20 (0.08,0.49)

<0.001

/

/

 

GU vs. gastritis/FD

3

93/139

3.55 (0.71,17.77)

0.123

76.00%

0.016

 

DU vs. gastritis/FD

2

60/91

3.15 (0.28,35.66)

0.354

87.10%

0.005

 

GC vs. gastritis/FD

4

101/215

2.09 (0.51,8.66)

0.308

79.10%

0.002

 
  1. The statistically significant results were highlighted in bold.
  2. a, P value for heterogeneity test; b, P value for Breslow-Day test.
  3. Abbreviations: FD functional dyspepsia, PUD peptic ulcer disease, GU gastric ulcer, DU duodenal ulcer, GC gastric cancer.
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BMC Infectious Diseases

ISSN: 1471-2334

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