Reason for treatment failure | Alternative given | |
---|---|---|
Voriconazole arm | LAmB arm | |
Infusion-related reactionsa | Caspofunginb | Voriconazolec |
Nephrotoxicity | Caspofunginb | Caspofunginb |
Hepatotoxicity | LAmBd | Caspofunginb |
Suspected fungal infection | LAmBe | Voriconazolec |
Persistent fever | LAmBe | Voriconazolec |
Breakthrough fungal infection | ||
Aspergillus spp. | LAmBd | Voriconazolec |
Candida spp. | Caspofunginb | Caspofunginb |
Zygomycetes spp. | LAmBe | N/A |
DematiaceousMoulds | N/A | LAmB plus posaconazolef |
Moulds not identified | N/A | LAmBe |
Non-responding baseline fungal infection | ||
Aspergillus spp. | LAmBd | Voriconazolec |
Candida spp. | Caspofunginb | Caspofunginb |
Zygomycetes spp. | LAmB plus posaconazolef | N/A |
Trichoderma fungemia | N/A | Voriconazolec |
Fusarium spp. | N/A | LAmB plus posaconazolef |
Moulds not identified | N/A | LAmB plus posaconazolef |