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Table 2 Resistance difference to ciprofloxacin and levofloxacin in Enterobateriaceae with various mutations in GyrA

From: Specific patterns of gyr A mutations determine the resistance difference to ciprofloxacin and levofloxacin in Klebsiella pneumoniae and Escherichia coli

Mutation

No. of isolatesa

No. of isolates with different susceptibilities to ciprofloxacin and levofloxacinb

P value

CIP-R LEV-R

CIP-R LEV-S

CIP-S LEV-R

CIP-S LEV-S

No mutation

66 (29)

4 (0)

1 (0)

0

61(29)

>0.05

mutation

261(154)

211(136)

21(7)

0

30(12)

9.54E-07

Ser83Tyr

10 (9)

2 (1)

4(4)

0

4 (4)

>0.05

Ser83Ile

10 (1)

8(1)

1(0)

0

1 (0)

>0.05

Ser83Phe

7 (6)

1(0)

2(2)

0

4 (4)

>0.05

Asp87Asn

1 (0)

0

1(0)

0

0

-

Ser83Thr

3 (0)

0

0

0

3 (0)

-

Ser83Ala

1(1)

0

0

0

1(1)

-

Ser83Leu

14(1)

4(0)

1(0)

0

9 (1)

>0.05

Ser83Leu+Asp87Asn

169 (96)

152 (96)

11(0)

0

6 (0)

1.00E-03

Ser83Leu+Asp87Tyr

38 (34)

37(33)

0

0

1 (1)

>0.05

Ser83Phe+Asp87Asn

4(4)

3(3)

1(0)

0

0

-

Ser83Phe+Asp87Tyr

1(1)

0

0

0

1(1)

-

Ser83Tyr+Asp87Tyr

1 (1)

1 (1)

0

0

0

-

Ser83Leu+Asp87His

1(0)

1(0)

0

0

0

-

Ser83Phe+Asp87Ala

1(0)

1(0)

0

0

0

-

Total

327(183)

214 (135)

22(7)

0

91 (41)

4.77E-07

  1. a: Numbers in brackets are isolates number in references.
  2. b: CIP, ciprofloxacin; LEV, levofloxacin.