Mutation | No. of isolatesa | No. of isolates with different susceptibilities to ciprofloxacin and levofloxacinb | P value | |||
---|---|---|---|---|---|---|
CIP-R LEV-R | CIP-R LEV-S | CIP-S LEV-R | CIP-S LEV-S | |||
No mutation | 66 (29) | 4 (0) | 1 (0) | 0 | 61(29) | >0.05 |
mutation | 261(154) | 211(136) | 21(7) | 0 | 30(12) | 9.54E-07 |
Ser83Tyr | 10 (9) | 2 (1) | 4(4) | 0 | 4 (4) | >0.05 |
Ser83Ile | 10 (1) | 8(1) | 1(0) | 0 | 1 (0) | >0.05 |
Ser83Phe | 7 (6) | 1(0) | 2(2) | 0 | 4 (4) | >0.05 |
Asp87Asn | 1 (0) | 0 | 1(0) | 0 | 0 | - |
Ser83Thr | 3 (0) | 0 | 0 | 0 | 3 (0) | - |
Ser83Ala | 1(1) | 0 | 0 | 0 | 1(1) | - |
Ser83Leu | 14(1) | 4(0) | 1(0) | 0 | 9 (1) | >0.05 |
Ser83Leu+Asp87Asn | 169 (96) | 152 (96) | 11(0) | 0 | 6 (0) | 1.00E-03 |
Ser83Leu+Asp87Tyr | 38 (34) | 37(33) | 0 | 0 | 1 (1) | >0.05 |
Ser83Phe+Asp87Asn | 4(4) | 3(3) | 1(0) | 0 | 0 | - |
Ser83Phe+Asp87Tyr | 1(1) | 0 | 0 | 0 | 1(1) | - |
Ser83Tyr+Asp87Tyr | 1 (1) | 1 (1) | 0 | 0 | 0 | - |
Ser83Leu+Asp87His | 1(0) | 1(0) | 0 | 0 | 0 | - |
Ser83Phe+Asp87Ala | 1(0) | 1(0) | 0 | 0 | 0 | - |
Total | 327(183) | 214 (135) | 22(7) | 0 | 91 (41) | 4.77E-07 |