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Table 1 Summary of common factors associated with altered pharmacokinetics of antibiotics in critically ill patients

From: How do we use therapeutic drug monitoring to improve outcomes from severe infections in critically ill patients?

Increased Vd

Decreased Cl

Increased Cl

Variable changes in Vdand/or Cl

Hypoalbuminaemia, leading to increased unbound drug

Renal hypoperfusion

Augmented renal clearance

Extracorporeal interventions (eg RRT, ECMO)

Capillary leakage

Acute kidney injury

  

Fluid resuscitation

Renal/hepatic dysfunction

  

Third space loss

   
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BMC Infectious Diseases

ISSN: 1471-2334

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