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Figure 3 | BMC Infectious Diseases

Figure 3

From: Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response

Figure 3

Modular analysis of genes associated with a higher response to vaccination. Genes whose expression correlate with the IFNg ELISpot response were identified using the R package SAM (a) and ranked in order of their score. The ranked list was then analysed in GSEA using the Blood Transcription Modules compiled by Li et al. as the reference gene set [33]. The results of the analysis for genes expressed in PBMC taken pre-vaccination or whole blood taken one day post-vaccination are shown (b). Length of the bar shows Normalised enrichment score for each module, number in the bars indicates genes in the test list present ineach reference set. Colour saturation indicates genes present as a percentage of total genes within the module (signal). Red modules are positively associated with ELISpot response, blue modules are negatively associated.

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