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Table 2 Distribution of the frequencies of KIR genes in patients with leprosy and their clinical forms and healthy individuals in the population of Rondonopolis, MT

From: Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil

Genes

Per se

LL

Borderline

TT

Controls

N = 408

N = 21

N = 302

N = 60

N = 413

n (%)

n (%)

n (%)

n (%)

n (%)

KIR2DL1

355 (87.0)a

19 (90.4)

260 (86.0)a

56 (93.3)

397 (96.2)a

KIR2DL2

290 (72.0)

14 (66.6)

209 (69.2)

48 (80.0)

300 (72.6)

KIR2DL3

363 (88.9)

18 (85.7)

272 (90.0)

53 (88.3)

380 (92.0)

KIR2DL4

405 (99.2)

21 (100)

300 (99.3)

60 (100)

409 (99.0)

KIR2DL5

227 (55.6)

8 (38.0)

167 (55.2)

36 (60.0)

225 (54.4)

KIR3DL1

388 (95.0)

21 (100)

286 (94.7)

58 (96.6)

392 (94.9)

KIR3DL2

405 (99.2)

21 (100)

301 (99.6)

59 (98.3)

413 (100)

KIR3DL3

406 (99.5)

21 (100)

301 (99.6)

60 (100)

413 (100)

KIR2DS1

151 (37.0)

5 (23.8)

112 (37.0)

25 (41.6)

156 (37.7)

KIR2DS2

215 (52.6)

10 (47.6)

159 (52.6)

30 (50.0)

197 (47.6)

KIR2DS3

123 (30.1)

4 (19.0)

90 (29.8)

19 (31.6)

129 (60.5)

KIR2DS4

387 (94.8)

21 (100)

286 (94.7)

57 (95.0)

386 (93.4)

KIR2DS5

144 (35.2)

5 (23.8)

107 (35.4)

23 (38.3)

157 (38.0)

KIR3DS1

148 (36.2)

4 (19.0)b

107 (35.4)

26 (43.3)b

153 (37.0)

  1. NOTE: Data represent the number of KIR genes and values in parentheses correspond to the percentages of each gene. TT: Tuberculoid, Borderline (BL, BB, BT), LL: Lepromatous.
  2. a KIR2DL1: P < 0.001, Pc < 0.014, OR = 0.26 (0.15 – 0.48) to per se vs. controls P < 0.001, Pc < 0.014, OR = 0.24 (0.13 – 0.45) to Borderline vs. controls.
  3. b KIR3DS1: P = 0.07 (tendency) to TT vs. LL.