Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil

Table 4 Stepwise logistic regression analysis of factors associated with the development of leprosy and its clinical forms

Variable response	Variable independent	Coefficient (β)	P	OR	-2Log
per se vs. controls	KIR2DL1	-2.227	0.001	0.10	1060.2
	KIR2DL1 - C2/C2	0.431	0.022	1.54
	KIR2DS2 - C1	0.537	0.002	1.71
LL vs. controls	Gender	-1.217	0.047	0.29	141.9
	KIR2DL1	-2.815	0.001	0.06
	KIR2DL2/2DL2 - C1	1.612	0.042	5.01
Borderline vs. controls	KIR2DL1	-1.868	0.001	0.15	936.9
TT vs. controls	Gender	0.755	0.017	2.13	288.5
	Ethnic	0.365	0.048	1.44
	KIR2DL1 ^e	-3.708	0.001	0.02
	KIR2DL1 - C2/C2	1.612	0.001	5.01
	KIR2DL2 - C1	1.452	0.001	4.27
	KIR2DL2/2DL2 - C1	1.173	0.059	3.23
TT vs. Borderline	Gender^a	0.947	0.002	2.57	281.7
	Ethnic	0.410	0.017	1.50
	KIR2DL1	-1.809	0.001	0.16
	KIR2DL1 - C2/C2	1.932	0.001	6.90
	KIR2DL2 - C1	1.840	0.001	6.30
TT vs. LL	Gender	1.783	0.004	5.95	82.4
Borderline vs. LL	KIR2DL2/2DL2 - C1	-1.579	0.024	0.206	151.3

NOTE: To this analysis, only KIR genes that were significant in the chi-square analysis were considered. (β): Coefficient of variables; -2Log: Logarithm of chance. Tuberculoid (TT), Borderline (BL, BB, BT), and Lepromatous (LL).

ISSN: 1471-2334