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Table 1 Characteristics of case series and RCT studies including in the qualitative analysis, according to treatment target (initial, gram-positive and gram-negative rods) and the patient’s renal basal disease

From: Efficacy of antibiotic therapy for peritoneal dialysis-associated peritonitis: a proportional meta-analysis

Study

All studies

Initial treatment/Negative culture

Gram +

Gram -

Total of studies (case series and RCTs)

84 [15-98]

44 [15-24,26,28,34,40,55,57,60-87]

36 [15,18,20-25,29,30,33-37,42,44,48,50,54,55,57,63,75,77,85,86,88-95]

32 [15,18,20,22,23,25,,31,32,35-37,39,41,45-47,49,50,52,55,57,63,69,77,78,86,91,93,96-98]

No. of patients/No. of episodes

9.268/16.109

4.411/7.315

3,526/6,259

2,549/4,925

Basal renal disease

    

Branchio-oto-renal syndrome

1

0

0

0

Chronic tubulointerstitial disease

2

1

1

0

Diabetes

51

16

14

10

Glomerulonephritis

33

12

10

6

Gouty

1

1

0

0

Hemolytic-uremic syndrome

1

0

0

0

Hypertension

21

13

8

5

IgA nephropathy

1

1

0

0

Interstitial nephritis

3

1

0

0

Systemic lupus

5

2

1

1

Malignancy

2

0

1

0

Multiple myeloma

1

0

0

0

Nephrosclerosis

2

2

2

0

Obstruction/Reflux

15

5

4

4

Others/unknown

25

11

8

3

Pyelonephritis

4

3

1

1

Policystic kidney disease

24

8

8

5

Renal artery stenosis

1

1

0

0

Renovascular

12

3

1

1

Systemic autoimmune disease

2

2

1

0

Comorbidities

    

AIDS

1

1

0

0

Cerebrovascular disease

7

1

2

0

Chronic lung disease

7

1

3

1

Connective tissue disorder

1

1

1

0

Congestive heart failure

2

1

1

0

Coronary heart disease

9

1

4

1

Current smoker

4

0

1

0

Dementia

2

1

1

0

Diabetes

16

6

8

5

Hemiplegia

2

1

1

0

Mild liver disease

2

1

1

0

Moderate or severe liver disease

3

2

1

0

Peptic ulcer disease

2

1

1

0

Peripheral vascular disease

9

1

2

0

Secondary hyperparathyroidism

1

0

1

1

Any Tumor, Leukemia, Lymphoma

4

2

3

1

Type of dialysis

    

CAPD

50

32

24

23

APD

11

7

7

7

Not reported

37

9

11

9

Any change from APD to CAPD

NR

NR

NR

NR

Mean age (years)

57,36

55,65

58,44

56,53

  1. NR = not reported; CAPD = continuous ambulatory peritoneal dialysis; APD = automated peritoneal dialysis; RCT = randomized clinical trial.