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Table 4 Immunological responses* among HIV-2 –infected patients in 17 studies

From: Antiretroviral therapy response among HIV-2 infected patients: a systematic review

Study (Author, year)

CD4 count Baseline Median [IQR]

CD4 count Month-6 Median [IQR]

CD4 count Month-12 Median [IQR]

CD4 count Month -24 Median [IQR]

Delta of CD4 count cells/mm3

Slope of CD4 count (first period)

Slope of CD4 count (second period)

Comments

Adje-Touré, 2003 [34]

82 [52–188]

154 [68–275]

163 [132–244]

NR

NR

NR

NR

NR

Van Der Ende, 2003 [29]

90 [10–360]

230 [40–380]

270 [60–410]

NR

NR

NR

NR

13 patients (Group II)

Mullins 2004 [39]

134[93–205]

NR

NR

NR

NR

NR

NR

Median of CD4 count at the last visit

327 [202–408]

Matheron, 2006 [40]

136 [57–244]

177

181

221

M6: +53 (+10; +86)

NR

NR

At 12 months

[98–328]

[123–290]

[133–374]

   

No PI: +40 (+18; +97)

   

M12: +41 (+9; +92)

   
   

M24: +62 (9; 120)

  

PI: (+41 (+8, +86)

      

P (0.67)

Ndour, 2006 [41]

204 [12–1029]

NR

NR

NR

Month-12

NR

NR

NR

   

+200 cells/mm3

   

Drylewicz, 2008 [12]

267 [163–381]

NR

NR

NR

NR

<2 months 25 (7; 42) cells/μl/months

>2 months-3 (-38; +32) cells/μl/year

Slope of % of CD4 count was reported

Ruelle 2008 [42]

226 [124–359]

NR

NR

NR

PI containing regimens: +89 cells/mm3 [-31; 323]

 

PI group 106 cells/μl/year

 

PI sparing regimens-53 cells/mm3 [-62; 57]

Without PI-25 cells/μl/year

Benard A, 2009 [28]

142 [59–259]

   

M6: +71 [11–116] M12: +122 [61–159] M24 + 132 [110–275]

<3 months 24.3 (7.1; 41.4) cells/μl/months

>3 months +8.50 (+5.3; +11.7) cells/μl/year

 

Jallow, 2009 [31]

145 [65–210]

NR

NR

NR

NR

NR

NR

NR

Gottlieb, 2009 [23]

200 [12–562]

NR

NR

NR

NR

NR

NR

NR

Harries, 2010 [17]

111 [31–171]

NR

NR

NR

NR

NR

NR

Means CD4 count M6 = 255, M12 = 270

Drylewicz 2010 [30]

178 [77–232]

NR

PI 278 [248–307] NNRTIs 268 [175–293]

NR

NR

<3 months NNRTIs: -41 (-123; 40) cells/μl/year

>3 months +8.50 (+5.3; +11.7) cells/μl/year

 

Smith 2010 [43]

202 [2–1124]

NR

NR

NR

  

+8 [-100; +181] cells/mm3/year

64% CD4 increase and 37% cd4 decline in follow-up

Chiara, 2010 [44]

96 [73–111] (3NRTIs)/PI (114)/78

3NRTIs/PI (102)/171

3NRTIs/PI (91)/254

NR

NR

NR

NR

NR

Peterson 2011 [18]

140 [50–310]

NR

NR

NR

M6: +120 cells M12: +115 cells M24: +285 cells M36: +280

NR

NR

NR

Benard, 2011 [15]

216 [150–287] PI: 191 [90–275] 3NRTI: 170 [72–275]

NR

PI (327) 3NRTI (191)

NR

NR

<3 months PI: +12 cells/μl/months 3NRTI: +6 cells/μl/months

3-12 months PI: +76 cells/μl/y 3NRTI: -60 cells/μl/y

> = 200 cells/mm3 PI: +52 cells/μl/y 3NRTI: -99 cells/μl/y

Peterson K, 2012 [45]

181 [96–200]

NR

NR

NR

NR

NR

NR

NR

  1. *Included only the study who reported immunological responses.
  2. NR: Not Reported.