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Table 5 Significant covariates within final regression models for ES and ED eligibility opportunities

From: Influence of real-world characteristics on outcomes for patients with methicillin-resistant Staphylococcal skin and soft tissue infections: a multi-country medical chart review in Europe

Level

ES eligibility (n = 1542)

ED eligibility (n = 1542)

 

OR (95% CI)

OR (95% CI)

Intercept

  

Patient baseline characteristics

 

Country (vs Ireland/United Kingdom)

  

  Czech Republic

0.91 (0.38–2.17)

2.18 (1.01–4.67)*

  Germany

2.47 (1.55–3.92)***

2.05 (1.30–3.24)**

  Greece

3.30 (1.99–5.48)***

1.39 (0.84–2.30)

  Portugal

1.75 (1.04–2.95)*

1.67 (0.99–2.83)

  Slovakia

0.55 (0.20–1.46)

0.29 (0.10–0.82)*

Patient living arrangements (vs at home with caregiver)

  

  Alone without caregiver

 

1.33 (1.03–1.72)*

Dementia

0.46 (0.28–0.76)**

0.50 (0.30–0.83)**

Infection/ treatment characteristics

 

Hospital-acquired or healthcare-associated infection

1.75 (1.30–2.37)***

1.69 (1.25–2.27)***

Days to first MRSA culture (vs on or before cSSTI index date)

  

  No MRSA culture documented

0.46 (0.30–0.69)***

0.58 (0.40–0.85)**

Days from admission to cSSTI index date (vs cSSTI at admission)

  

  ≥4 days after admission

0.47 (0.32–0.70)*

0.55 (0.38–0.79)

MRSA-targeted therapy patterns (vs IV-only)

  

  IV-to-oral antibiotic switch

0.49 (0.33–0.72)***

1.40 (1.00–1.96)

Time to initiating MRSA-active therapy (vs on or before cSSTI index date)

  

  1–2 days post cSSTI index date

 

1.20 (0.92–1.56)**

  ≥3 days post cSSTI index date

 

0.71 (0.51–0.99)**

Any surgical procedures for cSSTI

1.13 (0.87–1.45)

1.04 (0.82–1.32)

Complications

 

Developed IV line infection

0.19 (0.06–0.56)**

 

Hospital characteristics

 

Hospital had an IV-to-oral antibiotic switch protocol

 

0.58 (0.43–0.80)***

Hospital had an ED protocol (IV-to-oral antibiotic switch or OPAT)

 

1.86 (1.31–2.64)***

  1. *p < 0.05; **p < 0.01; ***p < 0.001.
  2. Full versions of the final models, including covariates that were statistically non-significant, are in Appendix Table 1.
  3. Abbreviations: CCI, Charlson comorbidity index; CI, confidence interval; cSSTI, complicated skin and soft tissue infection; IV, intravenous; ED, early discharge; ES, early switch; GP, general practitioner; IM, internal medicine specialist; LOS, length of hospital stay; MRSA, methicillin-resistant Staphylococcus aureus; OPAT, outpatient parenteral antibiotic therapy; SAE, serious adverse event; SE, standard error.