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Table 3 Mutations in rpoB, katG, gidB, pncA, gyrA, gyrB, rpsL, rrs, and tlyA genes associated with the formation of drug resistance and the following amino acid substitutions

From: Characterization of extensively drug-resistant Mycobacterium tuberculosis isolates circulating in Siberia

â„–

rpoB

katG

gidB

pncA

gyr A

gyrB

rpsL

rrs

tlyA

6

S531L, S540R

S315T

E92D

A-11G

S95T

No mutation

K43R

1401 A → G

L11L

9

S531L, S540R

S315T

E92D

I5T

D94A, S95T

No mutation

K43R

1401 A → G, DelA 1473396

L11L

15

S531L, S540R

S315T

L10R

T-7C

D94N, S95T

No mutation

No mutation

1401 A → G, 685 G → A

L11L

17

S531L, S540R

S315T

E92D

48InsG

D94H, S95T

No mutation

K43R

No mutation

L11L

20

L511P, D516G, S540R

S315T

E92D

L4W

S95T

No mutation

No mutation

No mutation

L11L

21

S531L, S540R

S315T

E92D

Y99STOP

A90V, S95T

No mutation

K43R

1401 A → G

L11L

37

S531L, S540R

S315T

E92D

T76P

D94A, S95T

No mutation

K43R

No mutation

L11L

38

S531L, S540R

S315T

E92D

L120P

D94E, S95T

No mutation

K43R

1401 A → G

L11L

48

D516V, S540R

S315T

L10R

T76P

A90V, S95T

No mutation

No mutation

1401 A → G

N/A

78

S531L, S540R

S315T

E92D

A28D

D94G, S95T

No mutation

K43R

No mutation

N/A

87

S531L, S540R

S315T

E92D

D12A

D94G, S95T

No mutation

K43R

No mutation

N/A

94

S531L

S315T

E92D

V139A

S91P, S95T

No mutation

K43R

1401 A → G

N/A

96

H513L

S315T

N/A

No mutation

D94N, S95T

No mutation

No mutation

No mutation

N/A

128

S531L

S315T

E92D

Del G pos256, S179V

N/A

No mutation

K88R

1401 A → G

L11L

133*

S531L

S315T

E92D

N/A

D94G, S95T

No mutation

K43R

1401 A → G

N/A

145

L533P, S540R

S315T

E92D

Del C pos 428

D94G, S95T

No mutation

K43R

No mutation

L11L

158

S531L

S315T

E92D

No mutation

S95T

No mutation

K43R

1401 A → G

N/A

169

S531L, S540R

S315T

E92D

A-11G

D94Y, S95T

No mutation

K43R

No mutation

L11L

171

S531L

S315T

E92D

No mutation

S95T

No mutation

K43R

No mutation

L11L

235

S531L

S315T

E92D

V7G

A90V, S95T

No mutation

K43R

No mutation

L11L

236*

S531L, S540R

S315T

E92D

N/A

D94G, S95T

No mutation

K43R

1401 A → G

L11L

238

S531L

S315T

I81I, E92D

V45G, I31S

D94G, S95T

No mutation

K43R

1401 A → G

L11L

275

S531L

S315T

E92D

No mutation

D94A, S95T

No mutation

K43R

1401 A → G

L11L

276

S531L

S315T

N/A

No mutation

S95T

No mutation

No mutation

1401 A → G

N/A

285

S531L

S315T

E92D

L172P

D94A, S95T

No mutation

K43R

1401 A → G

L11L

287

S531L

S315T

N/A

I31S

S91P, S95T

No mutation

K43R

1401 A → G

N/A

300

S531L, S540R

S315T

E92D, R102P

I31S

A90V, S95T

No mutation

K43R

1401 A → G

N/A

309

S531L, S540R

S315T

N/A

A146T

A90V, S95T

No mutation

K43R

1401 A → G

N/A

1084

S531L, S540R

S315T

N/A

D8N

D94N, S95T

No mutation

K43R

1401 A → G

N/A

4548

S531L

S315T

E92D

Del A pos 353

D94G, S95T

No mutation

K43R

1401 A → G

N/A

  1. Note: *- the isolates from one patient. N/A – we could not get the sequencing.