Changes in cytokine levels after 2 weeks of TB treatment follows three patterns. Cytokine levels at baseline and after two weeks of treatment in response to each antigen were determined for each patient. Cytokine levels were calculated by subtracting the background (value of un-stimulated control) from measured values for each cytokine. Data was analyzed using Wilcoxon signed rank test and P values <0.05 were considered significant. Shown are the cytokine profiles of patients (n = 12) who had both time points available for response to ESAT-6/CFP-10. In patients A1, L2, M10, M9 there is a significant decrease in all cytokine levels at week two, while in patients A6, M4, M2, M6, M5 there is a significant increase in all cytokine levels. The increase and decrease in cytokine levels in A5 and L1 respectively, are not significant while M1 shows fluctuating levels.