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Table 4 Cytokine production in response to HIV-1 p24 challenge

From: Proliferative capacity and cytokine production by cells of HIV-infected and uninfected adults with different helminth infection phenotypes in South Africa

Cytokine (pg/ml)

Phenotype subgroups

 

Median (minimum-maximum)

 

Egg+IgEhi(n = 10)

Egg+IgElo(n = 10)

Egg-IgEhi(n = 10)

Egg-IgElo(n = 9)

Pro-inflammatory

    

IL-6

46.5 (0–1410)

866 (0–4599)

573 (0–12483)

0 (0–1234)

IL-8

864 (0–5293)

1032 (0–3388)

591 (0–3690)

0 (0–1076)

TNF-alpha

20 (0–250)

7 (0–53)

30 (0–1380)

2.9 (0–217)

Anti-inflammatory

    

IL-1RA

5.1 (0–218)

22 (0–516)

0 (0–412)

11 (0–318)

Type one (Th1)

    

IL-2

0 (0–0)

0.40 (0–2.1)

0 (0–3.1)

0 (0–4.6)

IFN-Îł

0 (0–0)

11.1 (0–66)

1.9 (0–497)

1.4 (0–63.1)

IP-10

9.3 (0–104)

23.5 (0–101)

40.2 (0–1708)

78.9 (0–875)

GM-CSF

0 (0–96)

13.5 (0–65)

8.5 (0–227)

0 (0–96)

Type two (Th2)

    

IL-4

0 (0–4.7)

0 (0–4.8)

0 (0–7)

0 (0–2.3)

IL-5

0 (0–0)

0 (0–1.1)

0 (0–1.8)

0 (0–0.1)

IL-13

0 (0–2.2)

2.3 (0–45)

0(0–11.4)

0 (0–2.2)

Regulatory

    

IL-10

10.2 (0–110)

33.9 (0–95)

8.7 (0–305)

11.2 (0–105)

  1. Egg–Faecal helminth eggs, IgE–Ascaris lumbricoides-specific IgE, IgE hi/lo- high/low IgE in serum; IL–interleukin, IL-1RA–interleukin-1 receptor antagonist; IFNγ interferon gamma; IP-10 interferon-inducible protein 10, TNFαTumour– necrosis factor alpha, GM-CSF-granulocyte-monocyte stimulation factor, RPMIc–omplete RPMI medium.
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BMC Infectious Diseases

ISSN: 1471-2334

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